Liver fat in adults with GH deficiency: comparison to matched controls and the effect of GH replacement.

Clinical Endocrinology
Fabian MeienbergIan Godsland

Abstract

Existing data regarding the association between growth hormone deficiency (GHD) and liver fat content are conflicting. We aimed (i) to assess intrahepatocellular lipid (IHCL) content in hypopituitary adults with GHD compared to matched controls and (ii) to evaluate the effect of growth hormone (GH) replacement on IHCL content. Cross-sectional comparison and controlled intervention study. Cross-sectional comparison: Twenty-two hypopituitary adults with GHD and 44 healthy controls matched for age, BMI, gender and ethnicity. Intervention study: nine GHD patients starting GH replacement (GH Rx group) and nine GHD patients not starting replacement therapy (non-GH Rx group). Intervention study: GH replacement for 6 months in the GH Rx group, dosage was titrated to achieve normal IGF-1 levels. HCL content determined by proton magnetic resonance spectroscopy ((1) H MRS). Cross-sectional Comparison: There was no difference in IHCL content between GHD patients and healthy controls (1·89% (0·30, 4·03) vs 1·14% (0·22, 2·32); P = 0·2), and the prevalence of patients with hepatic steatosis (IHCL of ≥ 5·56%) was similar in the two groups (22·7% vs 15·9%; chi-square probability = 0·4). Intervention study: The change in IHCL content over 6 mont...Continue Reading

Associated Clinical Trials

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Citations

Jul 6, 2017·International Journal of Molecular Sciences·Yutaka Takahashi
Jun 20, 2019·International Journal of Molecular Sciences·Amedeo LonardoGiovanni Targher
Jul 6, 2019·Frontiers in Endocrinology·Adriana Claudia Lopes Carvalho-FurtadoLuciana Ansaneli Naves
Sep 7, 2019·Therapeutic Advances in Endocrinology and Metabolism·Valentina GuarnottaCarla Giordano
Nov 26, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kevin C J YuenAndrew R Hoffman
Dec 15, 2020·World Journal of Gastroenterology : WJG·Ze-Yu WuBing Chang
Jun 15, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Seok Jin KangHo-Seong Kim

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