Liver fibrogenesis: un update on established and emerging basic concepts

Archives of Biochemistry and Biophysics
Erica NovoStefania Cannito

Abstract

Liver fibrogenesis is defined as a dynamic and highly integrated process occurring during chronic injury to liver parenchyma that can result in excess deposition of extracellular matrix (ECM) components (i.e., liver fibrosis). Liver fibrogenesis, together with chronic inflammatory response, is then primarily involved in the progression of chronic liver diseases (CLD) irrespective of the specific etiology. In the present review we will first offer a synthetic and updated overview of major basic concepts in relation to the role of myofibroblasts (MFs), macrophages and other hepatic cell populations involved in CLD to then offer an overview of established and emerging issues and mechanisms that have been proposed to favor and/or promote CLD progression. A special focus will be dedicated to selected issues that include emerging features in the field of cholangiopathies, the emerging role of genetic and epigenetic factors as well as of hypoxia, hypoxia-inducible factors (HIFs) and related mediators.

Citations

Dec 3, 2020·Frontiers in Immunology·Claire E McQuittyLuca Urbani
Jan 26, 2021·Frontiers in Medicine·Rasmus Hvidbjerg GantzelHenning Grønbæk
Jun 1, 2021·Frontiers in Chemistry·Aziz EftekhariMagali Cucchiarini
Jun 10, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ivan RusynMartyn T Smith
Aug 8, 2021·Cells·Beatrice FogliaMaurizio Parola
Dec 23, 2021·Chinese Journal of Integrative Medicine·Ying LiJian-Xun Liu

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