Liver fibrosis associated with potential vinyl chloride and ethylene dichloride exposure from the petrochemical industry

The Science of the Total Environment
Tzu-Hsuen YuanChang-Chuan Chan

Abstract

The understanding of the relationship between exposure to carcinogenic vinyl chloride (VCM) and ethylene dichloride (EDC) and liver fibrosis is limited. This study aimed to investigate the associations between the urinary metabolite levels of VCM and EDC and the risk of liver fibrosis in residents living near a petrochemical complex. Our study comprised 447 adult residents of two townships with questionnaire survey and health examination near the largest petrochemical complex in central Taiwan. The urinary levels of thiodiglycolic acid (TdGA), the metabolite of VCM and EDC, were detected in study subjects. We utilized fibrosis-4 (FIB-4) as the noninvasive liver fibrosis index. Adjusted linear model was applied to evaluate the associations between the distance from the complex and the urinary TdGA levels. Adjusted logistic regression model was applied to evaluate the associations between the urinary TdGA levels and the risk of liver fibrosis. The study subjects living in the closer township had significant higher urinary TdGA levels than those living in the more distant township (269.6 ± 200.7 vs. 199.2 ± 164.7 μg/g creatinine) (p < 0.001). It showed that urinary TdGA levels were decreased 0.53-fold when the distances from the c...Continue Reading

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Citations

May 3, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Tzu-Hsuen YuanChang-Chuan Chan
Jun 14, 2021·Environmental Research·Chi-Hsin S ChenChang-Chuan Chan

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