PMID: 15354062Sep 9, 2004Paper

Liver fibrosis in asymptomatic polyvinyl chloride workers

Journal of Occupational and Environmental Medicine
Tun-Jen HsiaoTsun-Jen Cheng

Abstract

This study was designed to determine whether vinyl chloride monomer (VCM) exposure is associated with liver fibrosis. A total of 347 workers with occupational exposure to VCM were systemically examined using liver ultrasonography and routine liver function tests. Vinyl chloride monomer cumulative dose (ppm-month) was estimated by summing the products of air VCM concentration levels and months of employment. Liver fibrosis was defined in subjects with precirrhosis and cirrhosis of liver diagnosed using ultrasonography. Significantly increased risks of developing liver fibrosis were found in workers who had history of high exposure jobs (odds ratio 5.5, 95% confidence interval 1.7-25.4) when compared with workers who did not have history of high exposure jobs. We concluded that there was an increased risk of developing liver fibrosis in PVC workers who had high exposure to VCM.

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Citations

Aug 11, 2005·International Archives of Occupational and Environmental Health·Marco Maroni, Anna Clara Fanetti
Aug 10, 2007·Journal of Occupational Medicine and Toxicology·Mir Saeed AttarchiMaria Mazaheri
Jul 25, 2012·Clinics in Liver Disease·Soledad Larrain, Mary E Rinella
Nov 11, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Matt CaveCraig J McClain
Oct 20, 2009·Journal of Hepatology·Morris Sherman
Apr 10, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Elisa FrullantiCarlo Zocchetti
Mar 19, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Giuseppe MastrangeloUgo Fedeli
Sep 1, 2015·Toxicology and Industrial Health·Mansour Rezazadeh AzariZahra Yazdanbakhsh
Dec 25, 2012·Toxicologic Pathology·Banrida WahlangMatt C Cave
Dec 1, 2012·International Journal of Toxicology·J Phillip KaiserScott C Wesselkamper
Jul 10, 2014·Journal of Korean Medical Science·Jung-Won Kim, Dong-Mug Kang
Sep 24, 2019·World Journal of Gastroenterology : WJG·Ugo FedeliGiuseppe Mastrangelo
Aug 10, 2018·Toxicology Research·James E KlaunigZemin Wang
Jun 14, 2020·The Science of the Total Environment·Tzu-Hsuen YuanChang-Chuan Chan
Oct 4, 2021·Journal of Applied Toxicology : JAT·Jin JiaYu-Lan Qiu

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