Liver fibrosis: noninvasive diagnosis with double contrast material-enhanced MR imaging

Radiology
Diego A AguirreClaude Sirlin

Abstract

To retrospectively evaluate the accuracy of double contrast material-enhanced (hereafter double-enhanced) magnetic resonance (MR) imaging depiction of hepatic fibrosis, with histopathologic analysis findings as the reference standard. The institutional review board approved this HIPAA-compliant study and waived the requirement for informed consent. One hundred one patients (58 men, 43 women; mean age +/- standard deviation, 52 years +/- 10) who underwent double-enhanced MR imaging with superparamagnetic iron oxide (SPIO)-enhanced and double-enhanced spoiled gradient-echo (SPGR) sequences between 2001 and 2004 and had a reliable reference standard for the diagnosis of liver fibrosis were included. Two blinded MR radiologists retrospectively scored qualitative (reticulation, nodularity, and total scores) and quantitative (contrast-to-noise ratio between hyperintense and hypointense liver regions, coefficient of variation, and noise-corrected coefficient of variation) liver texture features on MR images in consensus. The image scores for patients with advanced (METAVIR fibrosis score >/= 3) versus those for patients with mild (METAVIR score </= 2) fibrosis were compared, and receiver operating characteristic curves were determined...Continue Reading

References

Aug 1, 1989·Radiology·A Di LelioL Beretta
Dec 26, 1986·JAMA : the Journal of the American Medical Association
Aug 1, 1993·Digestive Diseases and Sciences·F FroehlichJ J Gonvers
Oct 1, 1995·Journal of Clinical Pathology·R OlssonS Wallerstedt
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K D LindorA R Zinsmeister
Jun 1, 1996·Gastrointestinal Endoscopy·J PoniachikE R Schiff
Nov 14, 1997·Gastroenterology·F ObertiP Calès
Apr 6, 1999·Journal of Hepatology·C AubéP Calès
Sep 2, 1999·AJR. American Journal of Roentgenology·K ItoN Matsunaga
Jan 17, 2002·Journal of Magnetic Resonance Imaging : JMRI·Daniel JirákMilan Hájek
Jan 31, 2002·World Journal of Gastroenterology : WJG·Pornpen Thampanitchawong, Teerha Piratvisuth
Aug 31, 2002·Radiology·Hitomi AwayaTsuneo Matsumoto
Oct 5, 2002·Clinics in Liver Disease·Jayant A Talwalkar, W Ray Kim
Jul 29, 2003·NMR in Biomedicine·Yvan BoulangerViviane Nicolet
Nov 8, 2003·World Journal of Gastroenterology : WJG·Lun-Gen LuXia-Qiu Zhou
Jan 24, 2004·Radiology·Hero K HussainIsaac R Francis
Jun 8, 2004·The American Journal of Gastroenterology·Nezam H Afdhal, David Nunes

❮ Previous
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Citations

Mar 28, 2007·Abdominal Imaging·Donald G MitchellRaphael Rubin
Feb 3, 2012·Abdominal Imaging·Luigi GrazioliEmanuela Orlando
Sep 15, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K Widhalm, E Ghods
Aug 21, 2008·Journal of Gastroenterology and Hepatology·N Cem BalciNecat Havlioglu
Mar 22, 2008·AJR. American Journal of Roentgenology·Chandana G LallKumaresan Sandrasegaran
Sep 22, 2007·AJR. American Journal of Roentgenology·Bachir TaouliHillel Tobias
Nov 26, 2009·AJR. American Journal of Roentgenology·Kumaresan SandrasegaranAlex M Aisen
Jun 18, 2010·World Journal of Gastroenterology : WJG·Akihiko OsakiYutaka Aoyagi
Apr 26, 2014·World Journal of Gastroenterology : WJG·Moon Young KimSoon Koo Baik
Jun 18, 2010·Pediatric Health·Nicole J BarshopJoel E Lavine
Jan 25, 2014·Journal of Translational Medicine·Cristina StasiAnna Linda Zignego
May 23, 2014·La Radiologia medica·Ahmed Abdel Khalek Abdel RazekTarek Barakat
Nov 22, 2012·Radiology·Vanja VarenikaBenjamin M Yeh
Dec 5, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Silvana C FariaClaude B Sirlin
Oct 13, 2006·Journal of Pediatric Gastroenterology and Nutrition·Heather M PattonJoel E Lavine
Oct 13, 2015·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Xuejun ZhangHiroshi Fujita
Feb 12, 2011·Expert Review of Gastroenterology & Hepatology·Kayur D PatelE Louise Thomas
Feb 4, 2012·Journal of Hepatology·Detlef Schuppan, Massimo Pinzani
Sep 1, 2010·Insights Into Imaging·Luis Martí-Bonmatí, Fructuoso Delgado
Feb 15, 2011·European Journal of Radiology·Tsutomu TamadaTeruki Sone
Nov 26, 2010·Magnetic Resonance Imaging Clinics of North America·Tatsuyuki TonanAliya Qayyum
Nov 9, 2010·Advances in Pediatrics·Sarah M LindbäckJeffrey B Schwimmer
Nov 21, 2009·European Journal of Radiology·Ahmed Abdel Khalek Abdel RazekKhaled Zalata

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