Liver fibrosis staging with a new 2D-shear wave elastography using comb-push technique: Applicability, reproducibility, and diagnostic performance

PloS One
Sang Min LeeSeung Yon Baek

Abstract

To evaluate the applicability, reproducibility, and diagnostic performance of a new 2D-shear wave elastography (SWE) using the comb-push technique (2D CP-SWE) for detection of hepatic fibrosis, using histopathology as the reference standard. This prospective study was approved by the institutional review board, and informed consent was obtained from all patients. The liver stiffness (LS) measurements were obtained from 140 patients, using the new 2D-SWE, which uses comb-push excitation to produce shear waves and a time-aligned sequential tracking method to detect shear wave signals. The applicability rate of 2D CP-SWE was estimated, and factors associated with its applicability were identified. Intraobserver reproducibility was evaluated in the 105 patients with histopathologic diagnosis, and interobserver reproducibility was assessed in 20 patients. Diagnostic performance of the 2D CP-SWE for hepatic fibrosis was evaluated by receiver operating characteristic (ROC) curve analysis. The applicability rate of 2D CP-SWE was 90.8% (109 of 120). There was a significant difference in age, presence or absence of ascites, and the distance from the transducer to the Glisson capsule between the patients with applicable LS measurements an...Continue Reading

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Citations

Mar 29, 2019·American Journal of Veterinary Research·Masahiro TamuraMitsuyoshi Takiguchi
May 28, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Dong Wook KimSeung Chai Jung
May 21, 2020·Der Radiologe·B TheekF Kiessling
Sep 13, 2020·Abdominal Radiology·Cheng Fang, Paul S Sidhu
Jan 21, 2021·Echocardiography·Aniela PetrescuJens-Uwe Voigt

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Methods Mentioned

BETA
biopsy
surgical resection

Clinical Trials Mentioned

NCT02673411

Software Mentioned

R
SPSS
MedCalc
R Package for Statistical Computing

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