Liver fluke (Fasciola hepatica)-derived peptides activate rat peritoneal mast cells

International Immunopharmacology
A TrudgettM Ennis

Abstract

Short peptides with sequences derived from those found in the tegumental antigen of Fasciola hepatica have been synthesised. Incubation of some of these peptides with rat peritoneal mast cells resulted in the degranulation of the cells as measured by a histamine release assay. This activity was shown to be associated with the proline-lysine-proline motif, which is responsible for the induction of mast cell degranulation by the mammalian bioactive peptide substance P. Studies on the mode of action of the fluke-derived peptide indicated that it was operating through the same biochemical pathways as substance P. The implications of these findings for the development of immune responses during parasite infections are discussed.

References

Sep 1, 1992·Experimental Parasitology·G V HillyerG Battisti
Jul 30, 1985·Biochimica Et Biophysica Acta·H ShibataK Tasaka
Jan 1, 1980·International Archives of Allergy and Applied Immunology·M EnnisF L Pearce
Nov 1, 1982·Veterinary Parasitology·C B Chapman, G F Mitchell
Jan 1, 1994·Immunopharmacology·M MousliC Bronner
Nov 1, 1993·Molecular and Biochemical Parasitology·A M SmithJ P Dalton
Nov 18, 1997·International Journal for Parasitology·E A Milbourne, M J Howell

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