Liver function and morphology after resuscitation from severe hemorrhagic shock with hemoglobin solutions or autologous blood

Critical Care Medicine
J EldridgeC Mackenzie

Abstract

To test the effects of three hemoglobin solutions on liver function and hepatic morphology after resuscitation from severe hemorrhagic shock. Prospective study. Laboratory. Thirty-three beagle dogs. Hemorrhagic shock was induced in anesthetized dogs by removal of blood at a rate of 2 mL/kg/min until systolic blood pressure (BP) reached 50 mm Hg. BP was maintained at this level 2 hrs by further withdrawing 5 to 10 mL aliquots whenever BP increased > 50 mm Hg. Resuscitation was then initiated with autologous whole blood (n = 7), 4% pyridoxalated-hemoglobin-polyoxyethylene conjugate (4% PHP [n = 6]), 8% pyridoxalated-hemoglobin-polyoxyethylene conjugate (8% PHP [n = 9], or 8% stroma-free hemoglobin (n = 7). Four dogs were managed identically but were not resuscitated. Gross necropsy and histologic examination of the liver were performed on all dogs after 7 days, or earlier if death occurred. In vitro interferences of PHP and stroma-free hemoglobin with liver function tests were determined and recommendations for interpretation of results from blood samples containing PHP and stroma-free hemoglobin were made. Blood was collected before, during, and after resuscitation from hemorrhagic shock. The dogs were then awakened and survivor...Continue Reading

References

Dec 1, 1967·The Journal of Experimental Medicine·S F RabinerL H Friedman
Apr 1, 1982·Critical Care Medicine·F H JeschK Messmer
Apr 1, 1982·Critical Care Medicine·C J Hauser, W C Shoemaker
Apr 1, 1982·Critical Care Medicine·H I Friedman, F DeVenuto
Jun 1, 1982·Archives of Surgery·C J HauserW C Shoemaker
Nov 1, 1993·Anesthesiology·C Rosow
Jun 1, 1994·Transfusion·T G Paglieroni, P V Holland

❮ Previous
Next ❯

Citations

Jul 10, 2002·Resuscitation·Laurence M KatzUNKNOWN Carolina Resuscitation Research Group
Aug 31, 2000·Critical Care Medicine·J CreteurJ L Vincent
Jun 26, 2001·The Journal of Surgical Research·S Rodríguez-ReynosoC Leal
Oct 12, 2000·Toxicologic Pathology·W L ChanM S Tam
Sep 29, 1998·The Journal of Trauma·F Rivera-ChavezR E Dean

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

© 2021 Meta ULC. All rights reserved