Liver function tests in patients with bacteremia.

Journal of Clinical Laboratory Analysis
Shinichiro KanaiTakehisa Matsumoto

Abstract

The purpose of this study was to evaluate liver function tests as potential indicators of bacteremia. We examined 156 patients with laboratory-confirmed bacteremia (bacteremia group) and 211 bacteremia-negative patients with bacterial infections (control group). The patients of the two groups had no underlying liver diseases. For patients in the bacteremia group, we analyzed liver function tests results obtained the day when the first positive blood culture was ordered. For those in the control group, the same data were obtained on the day when the first of multiple negative blood cultures was ordered. At t-test analyses, serum levels of gamma-glutamyl transpeptidase (gamma-GT) and alkaline phosphatase (ALP) were significantly higher, and those of albumin, total cholesterol, and cholinesterase were significantly lower in the bacteremia group than in the control group. Multivariate analyses found serum cholinesterase as an independent factor with adjusted odds ratio of 0.319 (per 65 U/L, standard deviation [SD] size). Serum level of C-reactive protein (CRP), on the other hand, showed no significant difference between the two groups. Serum levels of gamma-GT, ALP, albumin, total cholesterol, and cholinesterase more rapidly altere...Continue Reading

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Citations

Aug 29, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Keita MikiRussell L Delude
Jul 19, 2008·World Journal of Gastroenterology : WJG·Yukihiro Shimizu
Oct 3, 2014·World Journal of Hepatology·Masami MinemuraYukihiro Shimizu
Jul 19, 2008·Journal of Epidemiology·Yoriko AkizawaYukinori Kusaka
Jun 5, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Antonio GalanteMamatha Bhat
Oct 5, 2019·Journal of Clinical Medicine·Kyoung Hwa LeeYoung Goo Song

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