PMID: 6166325May 14, 1981Paper

Liver glycogen synthase in the developing foetal rat

Biochimica Et Biophysica Acta
C Watts, K R Gain

Abstract

Kinetic constants for liver glycogen synthase (UDPglucose: glycogen 4-alpha-D-glucosyltransferase, EC 2.4.1.11) with respect to UDPglucose have been measured in foetal liver homogenates from samples taken during late gestation (days 17-22) and the first hours after birth. The V of the inactive form of glycogen synthase increased markedly in this period and there was a significant increase in V of the active enzyme to a maximum at day 20 of gestation. The Km for UDPglucose measured in the presence of glucose-6-P (total activity) did not vary greatly, mean values of 0.51 +/- 0.04 mM. Values derived for the inactive enzyme were almost identical. In contrast, Km values for active glycogen synthase in foetal livers during gestation were significantly higher than those for adult liver. Highest values were seen at day 19 of gestation (1.84 +/- 0.08 mM) followed by a steady fall to 0.55 +/- 0.05 mM in the newborn compared with a mean value of 0.48 +/- 0.04 mM for adult liver. Existence of a reduced affinity of active glycogen synthase for UDPglucose must be recognized when assaying the enzyme in foetal liver, particularly when extrapolating values to rates of glycogen synthesis in vivo. Data were obtained only after removal of an amyla...Continue Reading

References

Dec 15, 1978·The Biochemical Journal·M Gilbert, J Bourbon
Nov 15, 1976·The Biochemical Journal·C Watts, E R Gain
Aug 1, 1973·The Biochemical Journal·A L Schwartz, T W Rall
May 1, 1974·The Biochemical Journal·P Devos, H G Hers
Jun 16, 1972·Biochimica Et Biophysica Acta·K SatoS Tsuiki
Dec 3, 1971·Biochemical and Biophysical Research Communications·Y Sanada, H L Segal
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·H J Mersmann, H L Segal
Aug 1, 1961·The Biochemical Journal·G N WILKINSON
Jun 4, 1963·Biochimica Et Biophysica Acta·F J BALLARD, I T OLIVER

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Citations

May 15, 1983·Experientia·H J BöhmeE Hofmann
Jun 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·N J GavrilovaM Dimitrova
Apr 1, 1994·Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology·N J Gavrilova, M S Setchenska
Dec 30, 1987·European Journal of Biochemistry·M PerezE Itarte

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