PMID: 9346634Mar 1, 1996Paper

Liver grafts can be preserved overnight

Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
J VixK Boudjema

Abstract

The introduction of University of Wisconsin solution has made liver transplantation a semi-elective procedure. However, many studies have suggested that cold storage must not exceed 12 hours to avoid ischemic-type biliary complications, to reduce the incidence of primary nonfunction and to improve graft and patient survival. The aim of this study was to compare the function of livers transplanted as soon as possible after the liver was harvested and those preserved overnight. Over a 42-month period, we studied 133 elective orthotopic liver transplantation procedures. When cold ischemia started after 6 PM, patients underwent transplantation the following morning (group A), whereas the remainder underwent transplantation immediately (group B). Cold ischemia lasted 13.7 hours and 9.5 hours in groups A and B, respectively (P < .001). The two groups were comparable in terms of initial and late biochemical liver function, the rates of primary nonfunction (6.5% in group A, 6.8% in group B), acute rejection (45.6% in group A, 45.7% in group B), and vascular and infectious complications. No ischemic-type biliary complications were observed. Graft and patient survival were similar in both groups (72.4% v 75.4% and 72.9% v 75.8% in groups...Continue Reading

References

Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Sanchez-UrdazpalR A Krom
Jun 1, 1992·Annals of Surgery·F O BelzerH W Sollinger
Feb 3, 1989·JAMA : the Journal of the American Medical Association·S TodoT E Starzl
Mar 19, 1988·Lancet·M KalayogluF O Belzer

Citations

Jan 16, 2014·The Indian Journal of Surgery·N SelvakumarSurg Capt Sudeep Naidu
Oct 29, 1998·The New England Journal of Medicine·P A Ubel, A L Caplan
Oct 26, 1999·Transplantation·R B Freeman
Jun 28, 2011·The Journal of Surgical Research·Rupesh Kotecha, Luis H Toledo-Pereyra

Related Concepts

Organ Preservation
Postoperative Complications
Transplantation of Liver

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