PMID: 9173682Apr 1, 1996Paper

Liver haem metabolism in adjuvant-induced arthritic rats

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
A TodaH Shimeno

Abstract

1. Adjuvant-induced arthritic (AA) rats show a striking decrease in the level of cytochrome P450, a key microsomal haemoprotein involved in electron transport and drug metabolism in the liver. In the present study, we examined the relationship between the reduction of P450 content and haem metabolism in the liver of AA rats. 2. The activities of many enzymes catalyzing the biosynthesis of haem in the liver were significantly higher in AA rats than in normal rats, whereas only coproporphyrinogen oxidase activity in AA rats was markedly lower than that in normal rats. Furthermore, the activity of haem oxygenase, a key enzyme in the haem degradative pathway, increased significantly in AA rats. In addition, the degree of increase in the activity of this enzyme was clearly higher than that in the activity of 5-aminolevulinate synthase, a key enzyme in the haem synthetic pathway. 3. These results suggest that the reduction of live P450 content in AA rats is based on the lowering of liver haem content due to the combined action of the increased haem oxygenase activity and the decreased coproporphyrinogen oxidase activity. The changes in these enzyme activities were apparently suppressed by the continuous administration of indomethacin...Continue Reading

References

Dec 15, 1976·Biochemical Pharmacology·M A CawthorneJ Green
Sep 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A TodaH Shigematsu
Aug 15, 1985·Analytical Biochemistry·P LabbeH Chambon
Feb 1, 1970·Biochemical Pharmacology·D M Morton, D H Chatfield
Jan 1, 1983·Pharmacology & Therapeutics·M E Billingham
Jul 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A TodaH Shimeno
Jan 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·C M PEARSON
Feb 1, 1964·Arthritis and Rheumatism·C M PEARSON

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Citations

Feb 21, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M AchiraT Kume
Jul 3, 2004·Ageing Research Reviews·Hani Atamna

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