Liver Imaging Reporting and Data System v2014 With Gadoxetate Disodium-Enhanced Magnetic Resonance Imaging: Validation of LI-RADS Category 4 and 5 Criteria

Investigative Radiology
Sang Hyun ChoiPyo Nyun Kim

Abstract

The aim of this study was to validate the Liver Imaging Reporting and Data System (LI-RADS) v2014 category 4 (LR-4) and 5 (LR-5) criteria on gadoxetate disodium-enhanced magnetic resonance imaging (MRI) in patients with chronic liver disease. Between January and December 2012, 300 patients with chronic liver disease who had hepatic nodules 3.0 cm or smaller at surveillance ultrasonography and gadoxetate disodium-enhanced MRI were included. LI-RADS category was retrospectively assigned to each nodule on MRI. Final diagnosis was assessed using pathologic diagnosis only (operation or core-needle biopsy) or pathologic and clinical diagnosis (marginal recurrence after treatment or a change in lesion size on follow-up imaging). To validate the LR-4 and LR-5 criteria, the sensitivity, positive predictive value (PPV), and false referral rate for diagnosing hepatocellular carcinoma were examined. Based on major imaging features only, 137 nodules were initially assigned as LR-3, but 133 (97.1%) were upgraded into LR-4 by the presence of ancillary features. Excluding the remaining 4 LR-3 and 3 LR-M nodules, we analyzed 379 nodules in 294 patients, consisting of 211 LR-4 and 168 LR-5 nodules. Using pathologic diagnosis only, the sensitivit...Continue Reading

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Citations

Mar 30, 2017·Abdominal Radiology·Victoria ChernyakClaude B Sirlin
Apr 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jorge A MarreroJulie K Heimbach
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Jun 6, 2017·Abdominal Radiology·Kathryn J FowlerStephanie R Wilson
Jun 15, 2017·Abdominal Radiology·An TangClaude B Sirlin
Jan 22, 2019·Clinical and Molecular Hepatology·Yeun-Yoon KimMyeong-Jin Kim
Oct 19, 2017·Abdominal Radiology·Cynthia SantillanClaude Sirlin
Feb 28, 2019·European Radiology·Cheng William HongClaude B Sirlin
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Jun 3, 2021·Biology·Cosmin CaraianiChristoph Dietrich

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