PMID: 9633879Jun 20, 1998Paper

Liver iron and fibrosis during long-term treatment with deferiprone in Swiss thalassaemic patients

British Journal of Haematology
P TonduryA Hirt

Abstract

Serum ferritin levels, hepatic histology and iron concentration were studied in a 'veteran' group of seven Swiss beta-thalassaemic patients after 93-99 months of treatment with the oral iron chelator deferiprone (L1), and another four patients who had received 54-82 months of L1 therapy. Despite continuous compliance, unexplained resurgence of serum ferritin levels occurred in 4/7 patients of the 'veteran' group after 4-5 years on L1. In three of these a concomitant increase of liver iron was also observed. Hepatic histology revealed significantly higher degrees of fibrosis in 6/11 hepatitis C (HC)-positive patients (fibrosis scores 1-5, mean 3.0) than in the HC-negative group (fibrosis score 0-2, mean 0.8). Two HC-negative patients had no detectable fibrosis after 98 and 93 months on deferiprone. Therefore the hepatic pathology in these patients cannot definitely be attributed as a side-effect of deferiprone. Chronic active hepatitis C and the accumulation of iron are the major causative factors to be considered.

References

Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B R Bacon, R S Britton
Dec 30, 1982·The New England Journal of Medicine·G M BrittenhamE M Bellon
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·M SchmidP U Heitz
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·M AkamatsuJ Suzumiya
Sep 1, 1994·The New England Journal of Medicine·N F OlivieriA R Cohen
Jul 21, 1998·Annals of the New York Academy of Sciences·A CohenF Tricta

❮ Previous
Next ❯

Citations

Jul 19, 2005·Annals of Hematology·Massimo Franchini
Aug 6, 2009·Annals of Hematology·Inusha PanigrahiRashmi R Das
Mar 2, 2005·Best Practice & Research. Clinical Haematology·A Victor Hoffbrand
Oct 16, 1999·Toxicology·M GómezM M Jones
Dec 2, 2000·Transfusion Science·G J KontoghiorghesA Kolnagou
Dec 4, 2001·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·C RoseP Fenaux
Feb 13, 2001·The International Journal of Biochemistry & Cell Biology·E Becker, D R Richardson
Jun 20, 1998·British Journal of Haematology·C HershkoG Link
Feb 26, 2000·British Journal of Haematology·A R CohenF Tricta
Nov 25, 2000·British Journal of Haematology·M J Pippard, D J Weatherall
Nov 13, 2001·British Journal of Haematology·J B Porter
Jul 9, 2002·British Journal of Haematology·Adriana CeciFernando Tricta
Dec 29, 1998·The New England Journal of Medicine·F Tricta, M Spino
Oct 25, 2002·The New England Journal of Medicine·David G Nathan, David J Weatherall
Nov 27, 2004·Acta Haematologica·A TaherA V Hoffbrand
Feb 2, 2010·Hematology/oncology Clinics of North America·Janet L Kwiatkowski
Apr 3, 2008·Pediatric Clinics of North America·Janet L Kwiatkowski
Dec 13, 2005·Annals of the New York Academy of Sciences·A PigaF Longo
Sep 9, 2005·European Journal of Haematology·M TsironiA Aessopos
May 7, 2005·European Journal of Haematology·Anna MeoRoland Fischer
Jul 31, 2007·British Journal of Haematology·Aurelio Maggio
Feb 14, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Dimitrios KountourasJohn Koskinas
Oct 30, 2004·Hematology/oncology Clinics of North America·Janet L Kwiatkowski, Alan R Cohen
Oct 3, 2003·Expert Opinion on Pharmacotherapy·Adriana CeciDomenico De Mattia
Dec 4, 2003·Expert Opinion on Pharmacotherapy·Karen F MurrayKris V Kowdley
Jul 20, 2002·Blood Reviews·L Merson, N Olivier
Nov 29, 2016·European Journal of Haematology·Sebastian BotzenhardtAntje Neubert
Apr 28, 2017·Expert Review of Hematology·Ami Belmont, Janet L Kwiatkowski
Jun 27, 2003·American Journal of Hematology·Timothy B Chaston, Des R Richardson
Aug 22, 2013·The Cochrane Database of Systematic Reviews·Sheila A FisherDavid J Roberts
Aug 24, 2013·The Cochrane Database of Systematic Reviews·Sheila A FisherDavid J Roberts
Nov 28, 2001·Hematology·J P KushnerN F Olivieri
Mar 15, 2003·Blood·A Victor HoffbrandChaim Hershko
Jun 27, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·George J KontoghiorghesAnnita Kolnagou
Mar 26, 2013·Toxicology and Industrial Health·Rhitajit SarkarNripendranath Mandal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.