PMID: 9187884May 1, 1997Paper

Liver iron influences the response to interferon alpha therapy in chronic hepatitis C

European Journal of Gastroenterology & Hepatology
S FargionG Fiorelli

Abstract

To define whether there is any relation between the iron status of patients with hepatitis C virus (HCV) chronic liver disease and their response to interferon therapy. To evaluate the long-term response to 1 year of interferon therapy with addition of phlebotomies after 3 months of treatment if at that time alanine aminotransferase (ALT) had not normalized in a group of patients with HCV-positive chronic liver disease whose iron status had been characterized. A northern Italian hospital. Fifty-eight anti-HCV-positive patients (four HCV-RNA negative) with biopsy proven chronic hepatitis and no evidence of iron overload as indicated by normal transferrin saturation at the time of enrollment in the study. Three times a week intramuscular injection of alpha interferon 3 MU for 1 year with addition of phlebotomies (350 ml/week) till iron depletion if after 3 months of interferon therapy ALT had not normalized. A long-term response was observed in 19 of the 52 patients who completed the treatment, four HCV-RNA negative and 15 positive. The four RNA-negative and seven of the 15 RNA-positive long-term responders had been treated with interferon alone, and the other eight also with phlebotomies. At univariate analysis only HCV genotype...Continue Reading

Citations

Jul 11, 2009·Annals of Hematology·Seyed-Moayed Alavian, Seyed-Vahid Tabatabaei
Dec 30, 1999·Clinical Biochemistry·M G NeumanP Marcellin
Sep 6, 2003·Alcohol·Herbert L BonkovskyYing Shan
Aug 2, 2000·Journal of Gastroenterology and Hepatology·S K Sarin
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M Di BisceglieB R Bacon
May 30, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Stephen PiankoLawrence M Blatt
Feb 3, 2005·Journal of Gastroenterology and Hepatology·Ivonete S S SilvaMaria Lucia G Ferraz
Apr 20, 2006·Clinical Evidence·Abdul Mohsen, Suzanne Norris
Jan 30, 2013·Viruses·Alexander V IvanovSergey N Kochetkov
Jun 30, 2014·Biological Trace Element Research·Salma Aslam ArainAbdul Haleem Panhwar
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R J FontanaH L Bonkovsky
Jun 15, 2007·Journal of Hepatology·Pi-Jung HsiaoKung-Kai Kuo
Aug 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nina Singh, Hsin-Yun Sun
Dec 29, 2013·Oxidative Medicine and Cellular Longevity·Mario ArcielloClara Balsano
Aug 22, 2008·Journal of Hepatology·Annika KauChristoph Sarrazin
Sep 1, 2009·Therapeutic Advances in Gastroenterology·Udayakumar NavaneethanGuy W Neff
Jan 26, 2002·The American Journal of Gastroenterology·Motoyoshi YanoKentaro Yoshioka
Jun 10, 2000·Journal of Viral Hepatitis·L A KondiliA Mele
Feb 8, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Richard D SembaDavid Vlahov
May 7, 1998·Journal of Gastroenterology and Hepatology·M J Burt, W G Cooksley
Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield
Jan 5, 2002·Antiviral Chemistry & Chemotherapy·M WrightH C Thomas
Dec 29, 1998·Antiviral Chemistry & Chemotherapy·J MainH C Thomas

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