PMID: 703533Aug 1, 1978Paper

Liver lipid alterations in rats fed arginine deficient diets

Lipids
J A Milner, E G Perkins

Abstract

Arginine deficiency is associated with a marked increase in liver lipids in the rat. Triglyceride accumulation accounts for most of the fatty infiltration. Cholesterol concentration per gram of liver increased approximately 280% above control rats receiving dietary arginine. The percentage of phospholipids was significantly decreased in the arginine-deficient rat liver compared to controls. The fatty acid composition revealed a significant reduction in the reduction in the percentage of palmitic, palmitoleic, oleic, and linoleic acids. However, both stearic and arachidonic acids were increased approximately 250 and 160%, respectively, in arginine-deficient livers compared to controls. Arginine deficiency in the rat causes a marked alteration in lipid metabolism similar to that observed with orotic acid feeding. The similarities or arginine deficiency and orotic acid feeding are discussed.

References

Feb 1, 1978·The Journal of Nutrition·Y H HaJ E Corbin
May 1, 1975·Metabolism: Clinical and Experimental·J A Milner, W J Visek
Nov 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·J A MilnerW J Visek
Sep 28, 1973·Nature·J A Milner, W J Visek
Nov 1, 1970·Analytical Biochemistry·R W HubbardD A Dubowik
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Feb 1, 1960·Proceedings of the National Academy of Sciences of the United States of America·R E HandschumacherL Hankin
Mar 1, 1968·Lipids·L F Eng, E P Noble

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Citations

May 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·Y AoyamaA Yoshida
Aug 1, 1981·Metabolism: Clinical and Experimental·A S Hassan, J A Milner
Nov 1, 1983·Atherosclerosis·D Kritchevsky
Mar 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·A Barbul
Jun 17, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joe Jongpyo LimJulia Yue Cui

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