PMID: 9280209Aug 1, 1997Paper

Liver microsomal membrane fluidity and microsomal desaturase activities in adult spontaneously hypertensive rats

Journal of Hypertension
C FoucherJ P Poisson

Abstract

The purpose of the present study was to investigate liver microsomal membrane fluidity simultaneously with membrane fatty acid composition and desaturase activities in spontaneously hypertensive rats (SHR). The membrane fluidity was determined, after electron spin resonance (ESR) measurement, in SHR compared with normotensive Wistar-Kyoto (WKY) rats, by calculating the order parameter S from ESR spectra of 5-nitroxide stearate and 10-nitroxide stearate, used as spin-labelled fatty acids. Desaturase activities were measured by incubating SHR and WKY rat liver microsomes with [14C]-radiolabeled fatty acids as substrates for desaturation reactions. The fatty acid composition of liver microsomal membranes was determined by gas-liquid chromatography. Whereas no significant difference between S of 5-nitroxide stearate was observed for SHR and WKY rats, S of 10-nitroxide stearate was significantly lower in SHR than it was in WKY rat microsomal membrane, indicating that the core microsomal membrane fluidity was higher in SHR. Significant differences between fatty acid compositions were observed for SHR and WKY rat microsomal membranes. Delta9 and n-6 delta6 microsomal desaturase activities were significantly lower in SHR. These results...Continue Reading

References

Dec 1, 1991·American Journal of Hypertension·A F Dominiczak, D F Bohr
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Citations

Sep 8, 1998·Seminars in Surgical Oncology·J M Jessup, M Loda
Jul 25, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J-L SavelliJ-P Poisson
Oct 16, 2003·Comptes rendus biologies·Jean-Luc SavelliJean-Pierre Poisson
Nov 24, 2005·Prostaglandins & Other Lipid Mediators·Fernanda Jurema MedeirosCarlos Alberto Mandarim-de-Lacerda
Jan 4, 2003·Hypertension·Pablo V EscribáValentina Ruiz-Gutiérrez
Dec 10, 2003·Hypertension·Regina AlemanyPablo V Escribá
Sep 17, 2002·European Journal of Biochemistry·Sonal P SanghaniWilliam F Bosron
Sep 14, 2007·Molecular Membrane Biology·Jesús PradesFrancisca Barceló
Feb 24, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J BellengerM Narce
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mahmood AkhtarDerek M McKay
Jul 30, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J L SavelliJ-P Poisson
Jun 24, 2004·Journal of Agricultural and Food Chemistry·Javier S Perona, Valentina Ruiz-Gutierrez

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