Liver mortality attributable to chronic hepatitis C virus infection in Denmark and Scotland--using spontaneous resolvers as the benchmark comparator

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Hamish A InnesL H Omland

Abstract

Liver mortality among individuals with chronic hepatitis C (CHC) infection is common, but the relative contribution of CHC per se versus adverse health behaviors is uncertain. We explored data on spontaneous resolvers of hepatitis C virus (HCV) as a benchmark group to uncover the independent contribution of CHC on liver mortality. Using national HCV diagnosis and mortality registers from Denmark and Scotland, we calculated the liver mortality rate (LMR) for persons diagnosed with CHC infection (LMRchronic ) and spontaneously resolved infection (LMRresolved ), according to subgroups defined by age, sex, and drug use. Through these mortality rates, we determined subgroup-specific attributable fractions (AFs), defined as (LMRchronic - LMRresolved )/LMRchronic , and then calculated the total attributable fraction (TAF) as a weighted average of these AFs. Thus, the TAF represents the overall fraction (where 0.00 = not attributable at all; and 1.00 = entirely attributable) of liver mortality attributable to CHC in the diagnosed population. Our cohort comprised 7,005 and 21,729 persons diagnosed with HCV antibodies in Denmark and Scotland, respectively. Mean follow-up duration was 6.3-6.9 years. The TAF increased stepwise with age. It...Continue Reading

References

Jul 16, 1999·International Journal of Epidemiology·K JuelE S Hansen
Sep 4, 1999·The New England Journal of Medicine·E Lawlor, G Columb
Jan 22, 2000·Annals of Internal Medicine·L B SeeffE L Kaplan
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M WieseU Oesen
Oct 19, 2002·The American Journal of Gastroenterology·Cassandra L Lehman, Ramsey C Cheung
Aug 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sharon J HutchinsonDavid J Goldberg
Sep 1, 2005·Drug and Alcohol Dependence·Jennifer V CampbellUNKNOWN STRIVE Project
Jun 6, 2006·Health Technology Assessment : HTA·M WrightUNKNOWN UK Mild Hepatitis C Trial Investigators
Dec 28, 2006·The Journal of Infectious Diseases·Ann-Brit Eg HansenNiels Obel
Jul 20, 2007·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Jason GrebelyMark W Tyndall
Nov 28, 2008·Statistical Methods in Medical Research·Scott A McDonaldDavid J Goldberg
Aug 27, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·David B ReinSarah B Lesesne
Oct 5, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lars Haukali OmlandUNKNOWN DANVIR Cohort Study
Jun 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samer S El-KamaryMichelle D Shardell
Jul 19, 2011·The International Journal on Drug Policy·V Anna Gyarmathy, Alan Neaigus
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Natasha K MartinMatthew Hickman
Nov 8, 2011·Annals of Internal Medicine·David B ReinCindy M Weinbaum
Jul 24, 2012·Drug and Alcohol Dependence·Chloe Le MarchandJudith A Hahn
Aug 8, 2012·BMC Infectious Diseases·Peer Brehm ChristensenSusan Cowan
Sep 11, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hamish A InnesUNKNOWN Hepatitis C Clinical Database Monitoring Committee
Feb 28, 2013·European Journal of Public Health·Sadie Boniface, Nicola Shelton
May 25, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mazen NoureddinMarc G Ghany
Aug 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason GrebelyUNKNOWN InC3 Study Group
Dec 18, 2013·Journal of Addiction Medicine·Dana E RileySamuel B Ho
Feb 11, 2014·Journal of Hepatology·Hamish InnesSharon J Hutchinson
Feb 12, 2014·International Journal of Epidemiology·Michael Roerecke, Jürgen Rehm
Apr 10, 2014·Journal of Viral Hepatitis·P BruggmannS J Hindman
Jun 22, 2014·Journal of Hepatology·Jenny StenkvistOla Weiland
Jun 27, 2014·European Journal of Epidemiology·Morten SchmidtHenrik Toft Sørensen
Sep 10, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joseph A BoscarinoUNKNOWN Chronic Hepatitis Cohort Study (CHeCS) Investigators

❮ Previous
Next ❯

Citations

Jul 27, 2018·Journal of Viral Hepatitis·Maryam DarvishianMel Krajden
Aug 5, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hamish InnesSharon J Hutchinson
Jan 17, 2019·AIDS·Nadine KronfliUNKNOWN Canadian Co-Infection Cohort Investigators
Apr 5, 2019·AIDS·Nadine KronfliUNKNOWN Canadian Co-Infection Cohort Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.