Liver regeneration and tumour stimulation: implications of the renin-angiotensin system

Liver International : Official Journal of the International Association for the Study of the Liver
Shir Lin KohChristopher Christophi

Abstract

Liver resection is the most effective treatment for primary liver tumours and metastasis to the liver, and remains the only potentially long-term curative therapy for patients with colorectal cancer (CRC) liver metastases. Nevertheless, there is a significant incidence of tumour recurrence following liver resection. Cellular and molecular changes resulting from resection and the subsequent liver regeneration process may influence the kinetics of tumour growth, contributing to recurrence. Although commonly associated with the systemic homeostasis of blood pressure, fluid and electrolyte, the renin-angiotensin system (RAS) has recently been shown to play a role in regulating cell proliferation, apoptosis and angiogenesis in local organs as well as in malignancies. An electronic search of the English literature on the role of the RAS in liver regeneration and tumourigenesis was performed using PubMed, with additional relevant articles sourced from reference lists. Studies have shown that the blockade of the RAS pathway stimulates liver regeneration and inhibits tumour progression. An understanding of the role of RAS in liver regeneration and tumourigenesis may enable alternative strategies to improve patient outcome and survival a...Continue Reading

References

Dec 1, 1992·American Journal of Hypertension·P B TimmermansR D Smith
Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G K Michalopoulos, R Zarnegav
Feb 1, 1992·Gut·A J Strain, J M Neuberger
Jan 1, 1990·Journal of Cardiovascular Pharmacology·E G Erdös
Feb 1, 1989·Archives of Surgery·R DoerrS A Cohen
Apr 1, 1989·The Surgical Clinics of North America·N C SaenzG D Steele
Feb 1, 1989·Archives of Surgery·M H CastilloM Goldrosen
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D S GrantE M Rosen
Nov 1, 1994·Diseases of the Colon and Rectum·I K PedersenH Baden
Nov 1, 1993·The British Journal of Surgery·W G JiangM C Puntis
Jul 1, 1993·Cancer Immunology, Immunotherapy : CII·G HeuffS Meyer
May 1, 1993·Clinical & Experimental Metastasis·W G JiangM B Hallett
Dec 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N FaustoE M Webber
Jun 14, 1996·Journal of Immunological Methods·T L ten HagenI A Bakker-Woudenberg
Nov 1, 1996·International Journal of Microcirculation, Clinical and Experimental·S P AndradeW T Beraldo
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Y FongM F Brennan
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances
Oct 10, 1997·Hypertension·C M FerrarioD I Diz
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T H KimG K Michalopoulos
May 5, 1999·Critical Reviews in Oncology/hematology·W JiangT Nakamura
May 25, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S O HoferH J Hoekstra
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 5, 2000·Life Sciences·R D MachadoS P Andrade
Mar 11, 2000·Archives of Histology and Cytology·T TakeishiM Naito
Jun 22, 2000·Biochemical and Biophysical Research Communications·H Wang, J A Keiser
Aug 3, 2000·Stem Cells·K E RodgersG S diZerega
Sep 9, 2000·Molecular Aspects of Medicine·G Poli
Jan 11, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F S RamalhoF M Corrêa
Feb 15, 2001·Circulation·M Burnier
Feb 24, 2001·CA: a Cancer Journal for Clinicians·Y Fong
Feb 24, 2001·Basic Research in Cardiology·L RössigA M Zeiher
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R D MachadoS P Andrade
Jul 27, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·K RodgersG Dizerega

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Citations

Feb 7, 2013·Clinical & Experimental Metastasis·P KrauseS Koenig
Dec 16, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Agnieszka Wanda Piastowska-CiesielskaTomasz Ochędalski
Feb 4, 2011·Digestive Diseases and Sciences·Yavuz BeyazitIbrahim C Haznedaroglu
Nov 1, 2012·The Journal of Surgical Research·Shir Lin KohChristopher Christophi
Apr 19, 2015·Clinics and Research in Hepatology and Gastroenterology·Mustafa CengizGulbanu Erkan
Jan 30, 2015·Digestive Diseases and Sciences·Yuko AriokaMitsuru Seishima
Oct 30, 2016·Journal of Gastroenterology and Hepatology·Linh NguyenChristopher Christophi
Jul 5, 2012·Acta Cirúrgica Brasileira·Maria de Lourdes Pessole Biondo-SimõesRogerio Ribeiro Robes
Apr 13, 2011·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·B EdwinA M Kazaryan
Dec 5, 2014·World Journal of Gastroenterology : WJG·Ji-Hua Shi, Pål-Dag Line
Sep 14, 2019·Endocrine Regulations·Paulina PidikovaIveta Herichova
Jan 27, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Tugrul PurnakErsan Ozaslan

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