Liver regeneration in aged mice: new insights

Aging
Monica Pibiri

Abstract

The regenerative capacity of the liver after resection is reduced with aging. Recent studies on rodents revealed that both intracellular and extracellular factors are involved in the impairment of liver mass recovery during aging. Among the intracellular factors, age-dependent decrease of BubR1 (budding uninhibited by benzimidazole-related 1), YAP (Yes-associated protein) and SIRT1 (Sirtuin-1) have been associated to dampening of tissue reconstitution and inhibition of cell cycle genes following partial hepatectomy. Extra-cellular factors, such as age-dependent changes in hepatic stellate cells affect liver regeneration through inhibition of progenitor cells and reduction of liver perfusion. Furthermore, chronic release of pro-inflammatory proteins by senescent cells (SASP) affects cell proliferation suggesting that senescent cell clearance might improve tissue regeneration. Accordingly, young plasma restores liver regeneration in aged animals through autophagy re-establishment. This review will discuss how intracellular and extracellular factors cooperate to guarantee a proper liver regeneration and the possible causes of its impairment during aging. The possibility that an improvement of the liver regenerative capacity in eld...Continue Reading

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Citations

May 21, 2020·International Journal of Molecular Sciences·Eva ErzarAndreja Erman
Sep 25, 2020·Biogerontology·Pynskhem Bok Swer, Ramesh Sharma
Jun 24, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alkistis-Maria PapatheodoridiAntonios Chatzigeorgiou
May 24, 2020·International Journal of Molecular Sciences·Fengming XuUta Dahmen
Feb 1, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joonyong LeeGuoli Dai
Jan 18, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joy X JiangNatalie J Török
Aug 21, 2019·Clinics and Research in Hepatology and Gastroenterology·Manon Allaire, Hélène Gilgenkrantz
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Fengming XuUta Dahmen
Nov 14, 2020·International Journal of Molecular Sciences·Shintaro YagiShinji Uemoto
Sep 23, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paul KernElvira Mass
Jan 6, 2022·Aging Cell·Raquel Maeso-DíazAnna Mae Diehl

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Methods Mentioned

BETA
nuclear translocation
GTPase
acetylation

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