Liver regeneration in fulminant hepatitis as evaluated by serum transforming growth factor alpha levels

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Tomoaki Tomiya, Kenji Fujiwara

Abstract

Transforming growth factor alpha (TGF alpha) is supposed to act as a mitogen for hepatocytes in an autocrine manner in vitro and in vivo. Retarded liver regeneration is a possible reason for poor prognosis of fulminant hepatitis (FH). We analyzed serum TGF alpha levels in patients with FH and patients with acute nonfulminant hepatitis (AH). Also, the relation of those levels to serum hepatocyte growth factor (HGF) levels and their changes after glucagon-insulin (G-I) therapy were studied. Maximal serum TGF alpha levels achieved in each case after admission until recovery from disease or death were correlated positively with maximal serum alanine transaminase (ALT) and total bilirubin levels in patients with AH, but negatively with maximal total bilirubin levels in patients with FH. Maximal serum TGF alpha levels in patients with FH were significantly higher in survivors than in nonsurvivors. Maximal serum HGF levels were positively correlated with maximal serum TGF alpha levels in patients with AH, but not in patients with FH. Multiple regression analysis indicated that G-I therapy was related to the increment of serum TGF alpha levels in patients with FH. These results suggest that serum TGF alpha levels are increased in accor...Continue Reading

Citations

May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C R Webster, M S Anwer
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yukiko InoueKenji Fujiwara
May 18, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xuehelati AihaitiToshimasa Asahara
Dec 17, 1997·Scandinavian Journal of Gastroenterology·T AnilkumarM Alison
Jan 8, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomoaki TomiyaKenji Fujiwara
Dec 20, 2003·Biochemical and Biophysical Research Communications·Tomoaki TomiyaKenji Fujiwara
Dec 21, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomoaki TomiyaKenji Fujiwara

❮ Previous
Next ❯

Related Concepts

Related Feeds