Liver retransplantation of more than two grafts for recurrent failure

Transplantation
Edip AkpinarAndreas G Tzakis

Abstract

Transplantation of more than two livers for recurring graft failure has not been specifically addressed in the literature. A retrospective analysis was conducted from a total of 2527 overall liver transplants at our institution. Main indications for multiple retransplant included primary nonfunction, chronic rejection, hepatic artery thrombosis, and recurrent disease. We identified 39 patients who received more than two grafts (32 received 3 grafts, 5 received 4 grafts, and 2 received 5 grafts). All patients required interposition arterial grafts from the aorta and hepatojejunostomy for the biliary reconstruction. Seventeen patients are still alive at last follow-up. Perioperative mortality rates after 3rd, 4th, and 5th liver graft were 25%, 14%, and 50%, respectively. Patient and graft survival rates were 72% and 56% at 1 year, respectively. Median length of stay was 27 days and median graft survival was 2.9 years. Selection of patients and a significant use of available resources are some of the important factors that clinicians need to take into account when dealing with multiple retransplantations. With such conditions, however, liver retransplantation of more than two grafts can be a life-saving procedure.

References

Nov 1, 1985·Seminars in Liver Disease·B W ShawT E Starzl
Nov 14, 1997·Annals of Surgery·J F MarkmannR W Busuttil
May 29, 1998·Transplantation·K A NewellJ R Thistlethwaite
Jan 12, 1999·Transplantation·H R Rosen, P Martin
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W R KimE R Dickson
Feb 24, 2001·Transplantation·E SiedersM J Slooff
Apr 20, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Scott W BigginsHugo R Rosen
Apr 30, 2003·Transplantation·Andreas G TzakisPhillip Ruiz
Sep 10, 2003·Transplantation Proceedings·I BilbaoC Margarit
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kymberly D S WattTimothy M McCashland
Nov 24, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Guy W NeffSteven M Rudich
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael A Zimmerman, R Mark Ghobrial
Jan 6, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Robert PfitzmannPeter Neuhaus
Apr 13, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C MageeA B Leichtman
Apr 21, 2007·Transplantation Proceedings·M UribeC Herzog
Sep 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Timothy McCashlandThomas Faust

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Citations

Jan 10, 2012·World Journal of Gastroenterology : WJG·Bjarte FosbyEspen Melum
Jul 16, 2014·Clinics in Liver Disease·William H KitchensJames F Markmann
Jul 23, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia BurraStefano Fagiuoli
Jan 19, 2016·Clinical Transplantation·Riccardo MemeoDenis Castaing
May 28, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Lena SibuleskyJustin H Nguyen
May 13, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paul D GreigLinda Wright
Jul 19, 2013·Clinical Transplantation·A KresselG E Loss
Jan 5, 2011·Clinical Transplantation·Susumu EguchiMaarten J H Slooff
Aug 31, 2010·Journal of Hepatology·José A CarriónXavier Forns
Apr 2, 2013·Clinics in Liver Disease·Andres F Carrion, Kalyan Ram Bhamidimarri
Jun 23, 2016·Pediatric Transplantation·Flavia FeierJoao Seda-Neto
May 4, 2017·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Konrad KobryńMarek Krawczyk
Nov 30, 2018·Transplantation·Jacob D de BoerUNKNOWN Eurotransplant Liver and Intestine Advisory Committee (ELIAC)
May 30, 2019·American Journal of Clinical Pathology·Thomas D SchianoM Isabel Fiel
Jun 1, 2013·Hepatology International·Hideya KameiDouglas Quan

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