Liver sinusoidal endothelial cell injury by neutrophils in rats with acute obstructive cholangitis

World Journal of Gastroenterology : WJG
Jian-Ping GongYong Peng

Abstract

The objective of this study is to elucidate the potential role of poly-morphonuclear neutrophils (PMN) in the development of such a sinusoidal endothelial cell (SEC) injury during early acute obstructive cholangitis (AOC) in rats. Twenty one Wistar rats were divided into three groups: the AOC group, the bile duct ligated group (BDL group), and the sham operation group (SO group). The common bile duct (CBD) of rats in AOC group was dually ligated and 0.2 ml of the E. Coli O(111) B(4) (5 X 10(9)cfu/ml) suspension was injected into the upper segment, in BDL group, only the CBD was ligated and in SO group, neither injection of E. Coli suspension nor CBD ligation was done, but the same operative procedure. Such group consisted of seven rats, all animals were killed 6h after the operation. Morphological changes of the liver were observed under light and electron microscope. Expression of intercellular adhesion molecule-1 (ICAM-1) mRNA in hepatic tissue was determined with reverse transcription polymerase chain reaction (RT-PCR). The serum levels of alanine aminotransferase (ALT) were determined with an autoanalyger and cytokine-induced neutrophil chemoattractant (CINC) was determined by enzyme-linked immunosorbent assay (ELISA). Neut...Continue Reading

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Citations

Oct 16, 2002·World Journal of Gastroenterology : WJG·Tong ZhouJian-Guo Geng
Jan 1, 2003·World Journal of Gastroenterology : WJG·Bin TuSheng-Wei Li
Oct 16, 2002·World Journal of Gastroenterology : WJG·Jian-Ping GongXu-Hong Li
Dec 12, 2003·World Journal of Gastroenterology : WJG·De-Sheng WangZheng-Cai Liu
Jun 5, 2002·World Journal of Gastroenterology : WJG·Jian-Ping GongXu-Hong Li
Dec 25, 2012·Molecular and Cellular Biochemistry·Devan Sabarinathan, Arambakkam Janardhanam Vanisree
Jul 12, 2019·The Journal of Clinical Investigation·Carolina Jimenez CalventeAriel E Feldstein
Mar 13, 2003·World Journal of Gastroenterology : WJG·Li-Li DaiChang-An Liu
Apr 8, 2004·World Journal of Gastroenterology : WJG·Feng ChengSheng-Fu Li
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