PMID: 639835Mar 17, 1978Paper

Liver size and indices of drug metabolism in alcoholics

European Journal of Clinical Pharmacology
H I PirttiahoR O Pelkonen

Abstract

The role of liver size in drug metabolism was investigated in 34 chronic alcoholics and 28 controls by comparing antipyrine half-life with biopsy content and total amount of hepatic cytochrome P-450 (P-450) and liver weight. Liver size was significantly greater in alcoholics than in controls. Total P-450 was increased and antipyrine metabolism was enhanced in alcoholics with normal histology of the liver. In subjects with alcoholic hepatitis or cirrhosis, the antipyrine half-life was prolonged and P-450 was decreased. Alcoholics with fatty liver had a reduced P-450 content, but the total amount of P-450 and the antipyrine half-life were normal. The results demonstrate in alcoholics that an enlarged liver of normal histological appearance is associated with enhanced drug metabolism. In subjects with fatty liver the drug metabolizing capacity per unit weight of liver is often impaired, but the increase in liver size leads to undisturbed total oxidizing capacity and normal in vivo metabolism. In alcoholic hepatitis drug metabolism is impaired in spite of hepatomegaly. In cirrhosis the enlargement of the liver appears to compensate for the decreased P-450 content resulting in only slightly decreased total P-450, and the severly imp...Continue Reading

References

Dec 1, 1977·Acta Radiologica: Therapy, Physics, Biology·H I Pirttiaho, U Pitkänen
Apr 20, 1977·European Journal of Clinical Pharmacology·E A SotaniemiP V Luoma
Feb 1, 1975·The Journal of Clinical Investigation·U KlotzG R Wilkinson
Nov 21, 1975·Science·E BaraonaC S Lieber
Mar 1, 1972·European Journal of Clinical Pharmacology·B SchoeneH F von Oldershausen
Mar 1, 1973·The Journal of Pharmacy and Pharmacology·L F PrescottE Roberts
Oct 1, 1974·Clinical Pharmacology and Therapeutics·U KlotzS Schenker
Dec 1, 1972·The American Journal of Medicine·J N CohnB Kotelanski
Sep 1, 1972·The British Journal of Ophthalmology·R Porter, A W Skillen
Jan 1, 1973·European Journal of Clinical Investigation·J BircherR Preisig
May 1, 1973·Clinical Pharmacology and Therapeutics·E A SotaniemiT K Larmi
Apr 1, 1974·European Journal of Clinical Investigation·P B AndreasenN Tygstrup
Jul 1, 1969·The American Journal of the Medical Sciences·R M KaterF L Iber
Mar 1, 1971·Clinical Pharmacology and Therapeutics·E S VesellG T Passananti
Mar 1, 1967·Medicine·T Barka, H Popper
Dec 1, 1968·Radiology·F D Rollo, F H DeLand

❮ Previous
Next ❯

Citations

Dec 1, 1994·Journal of Clinical Pharmacology·S C BoikeD K Jorkasky
Jan 1, 1986·International Archives of Occupational and Environmental Health·B DietzeC Brückner
Jan 1, 1981·European Journal of Clinical Pharmacology·M J BrodieD S Davies
Dec 28, 1977·European Journal of Clinical Pharmacology·E A SotaniemiJ Ahlqvist
Jul 1, 1979·European Journal of Clinical Pharmacology·U Breyer-PfaffF Petruch
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·J W Ryoo, R J Buschmann
Nov 1, 1980·Bulletin of Environmental Contamination and Toxicology·V KramplJ Kramplova
Jan 1, 1990·European Journal of Drug Metabolism and Pharmacokinetics·M HildebrandR Saller
Jan 1, 1982·Pharmacology & Therapeutics·O Pelkonen, E Sotaniemi
Jan 1, 1987·Pharmacology & Therapeutics·O Pelkonen, E A Sotaniemi
Jan 1, 1987·Pharmacology & Therapeutics·H Hoensch
Jan 1, 1989·Baillière's Clinical Gastroenterology·P A Arns, R A Branch
Sep 1, 1992·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T Wolff, M Strecker
Mar 31, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Darrell R BoverhofB Bhaskar Gollapudi
Sep 1, 1978·British Journal of Clinical Pharmacology·H I PirttiahoU Pitkänen
Oct 1, 1993·Alcoholism, Clinical and Experimental Research·V T SavolainenP J Karhunen
Jan 1, 1993·Pharmacology & Toxicology·J Sonne
Dec 1, 1988·The Journal of Clinical Investigation·J ReichenA Zimmermann
Jan 1, 1991·Drug Metabolism Reviews·A P NarangP Bambery
Aug 1, 1986·European Journal of Clinical Investigation·H P HoenschE E Ohnhaus
Apr 1, 1980·British Journal of Clinical Pharmacology·H I PirttiahoH Sundqvist
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J GeorgeG C Farrell
Sep 15, 1986·The Medical Journal of Australia·A Somogyi, P Rolan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Clinical Pharmacology
E A SotaniemiJ Ahlqvist
Acta Radiologica: Therapy, Physics, Biology
H I Pirttiaho, U Pitkänen
European Journal of Clinical Investigation
N CarulliG F Salvioli
© 2021 Meta ULC. All rights reserved