Liver slices in in vitro pharmacotoxicology with special reference to the use of human liver tissue

Toxicology in Vitro : an International Journal Published in Association with BIBRA
P OlingaG M Groothuis

Abstract

In the early years of research in in vitro pharmacotoxicology liver slices have been used. After a decline in the application of slices in favour of the use of isolated hepatocytes and the isolated perfused liver preparation, the development of the Krumdieck slicer in the 1980s led to a ;comeback' of the technique. This review will focus on the use of human liver, with special reference to the comparison of slices with isolated hepatocytes in in vitro pharmacotoxicology. In addition, an overview on the predictive value of these in vitro systems for drug disposition and toxicity in vivo will be given. Preservation techniques for liver slices and hepatocytes will also be discussed. These techniques ensure an efficient utilization of the scarce human material. For long-term storage of liver slices and hepatocytes, cryopreservation seems most promising. However, cryopreservation is still in its infancy, and reports mainly deal with drug metabolism studies after cryopreservation. Drug toxicity, metabolism and transport data determined in slices and isolated hepatocytes, from both human and animal liver showed good correlation with the corresponding parameters measured in vivo. Therefore, the results obtained in such studies may give...Continue Reading

References

Jan 1, 1976·Methods in Cell Biology·P O Seglen
Nov 15, 1976·Experientia·D A Young
Jan 1, 1978·Biochemical Pharmacology·P MoldéusA Norling
Feb 1, 1977·Clinical Pharmacology and Therapeutics·J KapitulnikA H Conney
Nov 1, 1976·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·H BojarC Broelsch
Sep 1, 1992·Anesthesia and Analgesia·H N GhantousK Brendel
Sep 1, 1991·Human & Experimental Toxicology·R FisherK Brendel
Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M G PoullainA Guillouzo
Jan 1, 1992·Toxicology and Applied Pharmacology·S AzriK Brendel
Feb 1, 1992·The Journal of Cell Biology·J C DunnM L Yarmush
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D SorrentinoC M Miller
Mar 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B LacarelleR Rahmani
Jun 1, 1991·Cryobiology·S M WishniesK Brendel
Feb 1, 1991·Cryobiology·D C MarshJ H Southard
Jun 1, 1991·Anesthesia and Analgesia·H N GhantousK Brendel
Apr 1, 1991·Cryobiology·R FisherK Brendel
Jan 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M J Gómez-LechónJ V Castell
Jul 31, 1990·European Journal of Biochemistry·F MorelA Guillouzo
May 14, 1990·Toxicology·H N GhantousK Brendel
Jun 1, 1990·Cryobiology·J A CoundourisG M Hawksworth
Apr 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F BerthouA Guillouzo
Jul 31, 1989·Biochemical and Biophysical Research Communications·J KwekkeboomH J Kempen
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J DichN Grunnet
Feb 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A GuillouzoP Koch
Apr 1, 1986·Pharmacological Research Communications·F BalletR Infante
Mar 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H W Ruelius
Dec 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·P F SmithK Brendel

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Citations

Jun 7, 2003·Toxicology and Applied Pharmacology·Esther F A BrandonJan H M Schellens
Oct 3, 2001·Journal of Hepatology·P OlingaG M Groothuis
Nov 25, 2000·Toxicology·C Lerche-Langrand, H J Toutain
Jan 23, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·I A M de Graaf, H J Koster
Feb 6, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·F ZuccoA Stammati
Jun 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E HashemiC Ioannides
Aug 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R GlöcknerD Müller
Aug 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R De KanterG M Groothius
Mar 29, 2001·Journal of Pharmacological and Toxicological Methods·S EkinsS A Wrighton
Aug 8, 2001·Journal of Pharmacological and Toxicological Methods·P OlingaG M Groothuis
Oct 21, 2003·Journal of Pharmacological and Toxicological Methods·Clare VerrillNick Sheron
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·D GruffatD Bauchart
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B N MelgertK Poelstra
Aug 22, 2007·Tissue Engineering·Yuet Mei KhongHanry Yu
Jun 17, 2005·Lipids·Dominique GruffatDominique Bauchart
Aug 24, 2012·Archives of Toxicology·Mackenzie HadiGeny M M Groothuis
Nov 28, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Muzeeb SyedSteen Honoré Hansen
Oct 23, 1998·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·D MüllerP Steinmetzer
Nov 6, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Janja PlazarGeny M M Groothuis
Apr 27, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Janja PlazarGeny M M Groothuis
Nov 4, 2004·Chemico-biological Interactions·Alison E M Vickers, Robyn L Fisher
Feb 9, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Peter OlingaGeny M M Groothuis
Aug 8, 2015·Inorganic Chemistry·Rajathees RajaratnamEric Meggers
Nov 22, 2007·Expert Opinion on Drug Metabolism & Toxicology·Inge Am de GraafPeter Olinga
Nov 8, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Brian G Lake, Roger J Price
Oct 14, 2014·Frontiers in Oncology·Robert D BennettSteven J Mentzer
Oct 9, 2014·Journal of Asian Natural Products Research·Yu-Shuai PengXiu-Wei Yang
Aug 9, 2012·Chemical Research in Toxicology·Mackenzie HadiGeny M M Groothuis
Apr 10, 2013·Chemical Research in Toxicology·Mackenzie HadiGeny M M Groothuis
Mar 9, 2000·Critical Care Medicine·M W NijstenJ H Zwaveling
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L BeljaarsK Poelstra
Jan 22, 2010·Cytotechnology·Martina ZimmermannUlrich M Lauer

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