Liver Stiffness Assessed by Shear Wave Elastography Predicts Postoperative Liver Failure in Patients with Hepatocellular Carcinoma

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Yinghao ShenHuichuan Sun

Abstract

Cirrhosis increases a patient's risk of developing postoperative liver failure (PLF). Liver stiffness (LS), assessed by two-dimensional shear wave elastography (SWE), indicates liver fibrosis with high accuracy. Whether LS is superior to portal hypertension (PHT) in predicting PLF remains to be studied. The study enrolled 280 patients who underwent hepatectomy for hepatocellular carcinoma from July 2015 to July 2016. All patients received preoperative assessments for LS, PHT, and serum markers of liver fibrosis in addition to other clinicopathological tests. Risk factors for grade A and grade B (or greater) PLF were subjected to univariate and multivariate analysis and receiver operating characteristic curve analysis. Fifty-five patients (19.6%) experienced PLF. The cutoff value of LS for predicting cirrhosis was 10.1 kPa. Multivariate analysis identified LS, hyaluronic acid, IV collagen, and the presence of splenomegaly as independent predictors of PLF. The cutoff value of LS for predicting PLF and grade B (or greater) PLF was 11.75 and 11.9 kPa, respectively. LS was superior to PHT in predicting PLF or greater than grade B PLF (0.72 vs. 0.60, 0.76 vs. 0.59, P < 0.05). LS measured by SWE can predict risk of PLF with greater ac...Continue Reading

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Citations

Dec 19, 2017·Frontiers in Physiology·Bruno ChristNavina Waschinsky
Jun 20, 2020·Seminars in Liver Disease·Mattias MandorferThomas Reiberger
Jun 20, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Chong-Chi ChiuHon-Yi Shi
Dec 1, 2017·Expert Review of Gastroenterology & Hepatology·Han DengXiaozhong Guo
Jul 6, 2021·Journal of Clinical and Translational Hepatology·Bin XuHui-Chuan Sun

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