PMID: 8987082Dec 1, 1996Paper

Liver targeting of interferon through pullulan conjugation

Pharmaceutical Research
K XiYoshito Ikada

Abstract

The purpose of this study was to actively target interferon (IFN) to the liver through its chemical conjugation with pullulan, a water-soluble polysaccharide with a high affinity for the liver. Chemical conjugation of IFN with pullulan was achieved by a cyanuric chloride method. Following intravenous injection of the conjugates to mice, their body distribution and the activity of an IFN-induced enzyme, 2', 5'-oligoadenylate (2-5A) synthetase in the liver and other organs, were evaluated. The cyanuric chloride method enabled us to prepare an IFN-pullulan conjugate that retained approximately 7-9% of the biological activity of IFN. Pullulan conjugation enhanced the liver accumulation of IFN and the retention period with the results being reproducible. When injected intravenously to mice, the IFN-pullulan conjugate enhanced the activity of 2-5A synthetase in the liver. The activity could be induced at IFN doses much lower than those of free IFN injection. In addition, the liver 2-5A synthetase induced by conjugate injection was retained for 3 days, whereas it was lost within the first day for the free IFN-injected mice. IFN-pullulan conjugation was promising for IFN targeting to the liver with efficient exertion of its antiviral a...Continue Reading

Citations

Sep 13, 2007·Critical Reviews in Biotechnology·Mehrdad HamidiMahshid Foroozesh
Oct 29, 2017·Folia Microbiologica·Sehanat PrasongsukHunsa Punnapayak
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