Liver tissue oxygenation as measured by near-infrared spectroscopy in the critically ill child in correlation with central venous oxygen saturation

Intensive Care Medicine
Gabriele SchulzOskar Baenziger

Abstract

To evaluate the clinical usefulness of near-infrared spatially resolved spectroscopic quantitative assessment of liver tissue oxygenation for simple, non-invasive estimation of global tissue oxygenation in critically ill neonates and children. Prospective observational clinical study. A tertiary multidisciplinary neonatal and paediatric intensive care unit (23 beds). One hundred neonates and children consecutively admitted to the paediatric intensive care unit. Near-infrared spectroscopic single-point assessment of liver tissue oxygenation index (TOI(Liver)) was compared with global tissue oxygenation as measured by central venous oxygen saturation (SvO(2)) and derived haemodynamic parameters. Data were compared using linear and multiple regression analysis. Overall correlation between TOI(Liver)and SvO(2) was good ( r=0.72, p<0.0001). Multivariable regression revealed that SvO(2) alone explained 51% of the observed variance of TOI(Liver). However, our data demonstrated large inter-individual differences between SvO(2) and TOI(Liver) values. Near-infrared spatially resolved spectroscopic quantitative measurement of liver tissue oxygenation correlates well with SvO(2) in critically ill neonates and children. Large inter-individu...Continue Reading

Citations

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