Liver transplantation and multivisceral transplantation in the management of patients with advanced neuroendocrine tumours

World Journal of Gastroenterology : WJG
A K Clift, A Frilling

Abstract

Orthotopic liver transplantation (OLT) represents a generally accepted albeit somewhat controversially discussed therapeutic strategy in highly selected patients with non-resectable hepatic metastases from neuroendocrine tumours (NET). Whilst there are some exclusion criteria, these are not universally followed, and the optimal set of inclusion parameters for deeming patients eligible has not yet been elucidated. This is due to heterogeneity in the study populations, as well differing approaches employed and also divergences in selection criteria between centres. Recent data have suggested that OLT may represent the most efficacious approach in terms of overall and disease-free survival to the management of NET metastatic to the liver when conducted in accordance with the modified Milan criteria. Therefore, a consensus set of selection criteria requires definition to facilitate stringent and fair allocation of deceased-donor organs, as well as consideration for living-donor organs. In the context of classically non-resectable metastatic tumour bulk, multivisceral transplantation with or without the liver may also be indicated, yet experience is very limited. In this review, we discuss the diagnostic work-up of patients in whom ...Continue Reading

References

Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Y YaoJ P Roberts
Jul 19, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J I HerreroJ Prieto
Mar 31, 2005·Annals of Surgery·David GrantUNKNOWN Intestine Transplant Registry
Sep 30, 2005·Annals of Surgery·Andreas G TzakisPhillip Ruiz
Feb 25, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Frederike G I van VilsterenTimothy J Hobday
Jun 27, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Andrea FrillingChristoph E Broelsch
Sep 13, 2006·Virchows Archiv : an International Journal of Pathology·G RindiUNKNOWN European Neuroendocrine Tumor Society (ENETS)
Feb 24, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael OlaussonHåkan Ahlman
Aug 19, 2007·Journal of Hepatology·Vincenzo MazzaferroJorgelina Coppa
Mar 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Klaas P KoopmansElisabeth G E de Vries
Jul 8, 2008·Endocrine-related Cancer·Ulrich-Frank PapeBertram Wiedenmann
Oct 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mauricio SilvaJosé Mir
Jan 13, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Alexander HaugGabriele Pöpperl
Jan 23, 2009·The British Journal of Surgery·A FrillingC E Broelsch
May 19, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Eliano Bonaccorsi-RianiJan Lerut
Jan 5, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kareem M Abu-Elmagd
Feb 11, 2011·The New England Journal of Medicine·James C YaoUNKNOWN RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group
May 11, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francesco PanzutoMassimo Falconi
Jan 19, 2012·International Journal of Hepatology·N Thao T NguyenChristine A O'Mahony
Feb 4, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T KatoJ Emond
Jul 12, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andreas PfeiferAndreas Kjaer
Apr 3, 2013·Scandinavian Journal of Gastroenterology·Jonas VarkeyGustaf Herlenius
Jan 5, 2014·The Lancet Oncology·Andrea FrillingUNKNOWN Working Group on Neuroendocrine Liver Metastases
Jul 6, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Sheung Tat FanAndrea Frilling
Jul 12, 2014·The New England Journal of Medicine·Martyn E CaplinUNKNOWN CLARINET Investigators
Oct 3, 2014·Cancer·Andrea Frilling, Ashley K Clift
Jul 15, 2015·Journal of Surgical Oncology·Linda S SherMyron E Schwartz
Oct 16, 2015·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Cheng-Yong TangZhong-Jun Wu
Jan 6, 2016·Neuroendocrinology·U-F PapeUNKNOWN Vienna Consensus Conference participants
Mar 15, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·Irvin M ModlinMark Kidd
Apr 26, 2016·Transplantation Proceedings·B RaoS-M Jafri
May 3, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V MazzaferroL Mariani

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