Liver transplantation for alcoholic liver disease

Addiction Biology
Georges-Philippe PageauxD Larrey

Abstract

Although increasing numbers of alcoholic patients are being referred to liver transplant centres, liver transplantation for alcoholic liver disease still remains controversial, essentially because we are in an era of organ shortage. In fact, the main issue is the likelihood of relapse and its influence on outcome, because it is the possibility of returning to alcohol use that separates patients with alcoholic liver disease from those with other forms of chronic liver disease. In all proposed clinical guidelines of indications for referral and assessment for liver transplantation for alcoholic liver disease, the authors emphasize the risk of alcoholism recurrence and, thus, a multidisciplinary approach is required to select patients who are likely to comply with follow-up and not return to a damaging pattern of alcohol consumption after transplantation. It emerges from all clinical studies that when we take into account the usual criteria of success for liver transplantation, i.e. patient and graft survival, rejection rate and infection rate, alcoholic liver disease is a good indication for liver transplantation. Predictive factors for alcoholic relapse after liver transplantation have been assessed in numerous studies, often wi...Continue Reading

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Citations

Apr 12, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia Burra, Michael R Lucey
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Mar 15, 2005·Clinics in Liver Disease·Jamilé Wakim-Fleming, Kevin D Mullen

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