PMID: 9544415Apr 17, 1998Paper

Liver transplantation for neuropsychiatric Wilson disease

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
N KassamV G Bain

Abstract

Although neuropsychiatric manifestations are prominent in some patients with Wilson disease, there is little published information regarding the efficacy of liver transplantation for these patients. A 22-year-old male with advanced neurological impairment and prominent psychiatric manifestations due to Wilson disease who underwent liver transplantation is presented. After transplantation, the ceruloplasmin and copper studies normalized and eventually the Kayser-Fleischer rings disappeared. Neurological recovery was very slow and incomplete, and his behavioural and personality disorder was entirely unaffected. He committed suicide 43 months post-transplantation. A review of the small number of related published cases in the English language literature shows variable neurological recovery post-transplantation, but the course of psychiatric manifestations is virtually never described. This case suggests that one must be cautious regarding liver transplantation for Wilson disease in patients with prior psychiatric manifestations. Aggressive medical management is likely to be preferable in most cases.

Citations

May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eve A RobertsUNKNOWN Division of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada
Feb 17, 2018·Postgraduate Medical Journal·Claire Kelly, Marinos Pericleous
Mar 10, 2001·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·M A DewR L Kormos
Apr 15, 2011·Psychology, Health & Medicine·Abbe G BoekaJ Steve Bynon
Apr 14, 2015·Pediatric Gastroenterology, Hepatology & Nutrition·Jun Suk KimSung-Gyu Lee
Feb 9, 2012·World Journal of Hepatology·Andreea M Catana, Valentina Medici
Feb 1, 2012·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Orazio SorbelloLuigi Demelia
Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Joanna SeniówAnna Czlonkowska
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eve A RobertsUNKNOWN American Association for Study of Liver Diseases (AASLD)
Oct 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alexander ChiuSheung Tat Fan
Jul 27, 2001·Brain Research Bulletin·N T Watt, N M Hooper

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