Liver transplantation for primary and metastatic liver cancers

Transplant International : Official Journal of the European Society for Organ Transplantation
Emir Hoti, Rene Adam

Abstract

Liver transplantation for hepatic malignancies has emerged as a well-documented and proven treatment modality. However, early unsatisfactory results emphasized that only a highly selected patient population would benefit from transplantation. Currently, 15% of all liver transplants performed are for hepatocellular carcinoma (HCC). There is no controversy about the fact that liver transplantation for HCC in the adult population yields good results for patients whose tumour masses do not exceed the Milan criteria. It remains to be determined whether patients with more extensive tumours can be reliably selected to benefit from the procedure. In patients with small HCC at an early stage and preserved liver function, liver resection provides an alternative to transplant. Liver resection may offer similar survival results to orthotopic liver transplantation (OLT) in the short term, and does not carry the long-term effects of immunosuppression; however, long-term and disease-free survival favours liver transplantation. Very promising results have been obtained for cholangiocarcinoma treated by aggressive combination therapies, including chemo- and radiotherapy followed by OLT. Survival rate in these selected patients can approach that...Continue Reading

References

Oct 1, 1985·Annals of Surgery·S IwatsukiT E Starzl
Jan 1, 1995·World Journal of Surgery·I IhseS Tibblin
Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Apr 1, 1997·Annals of Surgery·H LangR Pichlmayr
Nov 22, 1997·International Journal of Radiation Oncology, Biology, Physics·M L FooS J Buskirk
Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·M UregoB I Carr
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
May 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·I De VreedeG J Gores
Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J FiguerasE Jaurrieta
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F P SarasinA Hadengue
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Y YaoJ P Roberts
Jan 31, 2002·Journal of Pediatric Surgery·A P PimpalwarJ de Ville De Goyet
Aug 30, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francis Y YaoJohn P Roberts
Sep 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Debra SudanAlan Langnas
Oct 3, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francis Y YaoJohn P Roberts
Oct 12, 2002·Gut·S A KhanUNKNOWN British Society of Gastroenterology
Dec 11, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Robert J FontanaJuan Arenas
Feb 1, 2003·European Journal of Gastroenterology & Hepatology·Anjali D AmarapurkarBernard C Portmann
May 13, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jean-Marc BigourdanPhilippe Wolf
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J Wallis Marsh, Igor Dvorchik
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jordi BruixJosep M Llovet
Sep 10, 2003·Transplantation Proceedings·R RoblesP Parrilla
Nov 25, 2003·Annals of Surgery·Jacques BelghitiReza Kianmanesh
Dec 4, 2003·Journal of Hepatology·René Adam, Massimo Del Gaudio
Jan 7, 2004·American Journal of Surgery·Robert SutcliffeNigel Heaton
Jan 28, 2004·Annals of Surgery·Umberto CilloDavide Francesco D'Amico
Jan 28, 2004·Annals of Surgery·Ricardo RoblesPascual Parrilla
Jan 31, 2004·Pediatric Blood & Cancer·J B OtteUNKNOWN International Society of Pediatric Oncology (SIOP)
Feb 5, 2004·The British Journal of Surgery·C-M Lo, S-T Fan
Mar 24, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sander FlormanMyron Schwartz
Apr 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Barbara Rosado, Gregory J Gores
Aug 21, 2004·Annals of Surgery·Satoru TodoUNKNOWN Japanese Study Group on Organ Transplantation
Sep 7, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Matteo RavaioliGian Luca Grazi
Oct 22, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jessica Y LeungRaymond T Chung
Oct 28, 2004·Gastroenterology·Myron Schwartz

❮ Previous
Next ❯

Citations

Jan 31, 2013·Annals of Surgery·Morten HagnessSvein Dueland
Jan 27, 2011·World Journal of Gastrointestinal Oncology·Georgios TsoulfasIoannis Kanellos
Mar 8, 2014·Journal of Gastrointestinal Cancer·Bijan Eghtesad, Federico Aucejo
Apr 30, 2010·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M LossH J Schlitt
Jan 6, 2011·Expert Opinion on Biological Therapy·Luc J W van der LaanQiuwei Pan
Nov 26, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Dec 10, 2013·Transplantation Proceedings·S NikeghbalianS A Malekhosseini
Aug 21, 2012·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Tone Karine VidnesMarit Helen Andersen
Oct 20, 2012·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Irinel Popescu, Sorin Tiberiu Alexandrescu
Mar 11, 2011·CA: a Cancer Journal for Clinicians·Kiran K Turaga, Larry K Kvols
Aug 4, 2010·Pediatric Blood & Cancer·Justus LieberSorin Armeanu-Ebinger
Dec 15, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Josh Levitsky, Gabriel C Oniscu
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Meiyan BaoXianghuo He
May 19, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Aksel FossSvein Dueland
Apr 24, 2014·Clinical Transplantation·Juan MejiaAllan Tsung
Nov 26, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John A StaufferJustin H Nguyen
Aug 15, 2009·Magyar sebészet·Imre Fehérvári
Jul 19, 2011·Best Practice & Research. Clinical Gastroenterology·Geir Hoff
Jun 23, 2011·Transplantation Proceedings·O UskudarC Chang
Dec 8, 2009·Current Problems in Surgery·Charles H ChaSharon M Weber
Aug 4, 2004·The Lancet Oncology·J Wallis MarshIgor Dvorchik
Apr 4, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Susumu EguchiMitsuhisa Takatsuki
Dec 25, 2010·Therapeutic Advances in Gastroenterology·Joseph Y ChangSunanda Kane
Oct 14, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Harald GrutMona Elisabeth Revheim
Jan 30, 2019·Current Opinion in Organ Transplantation·Pranit Chotai, Lea Matsuoka
Oct 10, 2014·Advances in Anatomic Pathology·Sean K WangXiming J Yang
Dec 14, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Toru Goto, Markus Selzner
Aug 10, 2019·Current Opinion in Organ Transplantation·Silvio NadalinFalk Rauchfuss
Mar 29, 2012·Scandinavian Journal of Caring Sciences·Marit Helen AndersenAksel Foss
Apr 1, 2015·Hepatic Oncology·Morten Hagness
Mar 7, 2019·Current Opinion in Organ Transplantation·Eve SimoneauKarim J Halazun
Apr 26, 2020·Langenbeck's Archives of Surgery·Juan GlinkaMartin de Santibañes
Apr 6, 2019·Canadian Journal of Gastroenterology & Hepatology·Uta HerdenBjoern Nashan
Apr 7, 2018·Canadian Journal of Gastroenterology & Hepatology·Andre GorgenGonzalo Sapisochin
Feb 6, 2017·Journal of Transplantation·Daniel SeehoferJohann Pratschke
Aug 9, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Jan LerutUNKNOWN European Liver, Intestine Transplantation Association (ELITA)
Feb 27, 2020·Gut and Liver·Kevin Ka-Wan ChuKenneth Siu-Ho Chok
May 13, 2021·Clinics in Liver Disease·Akshata MogheNaudia Jonassaint

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Transplant International : Official Journal of the European Society for Organ Transplantation
Aksel FossSvein Dueland
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Nicholas OnacaGöran B Klintmalm
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Walid FarajNigel Heaton
© 2022 Meta ULC. All rights reserved