PMID: 9434032Jan 20, 1998Paper

Liver transplantation for severe hypoxemia caused by patent ductus venosus

Journal of Pediatric Surgery
T OriiS Satomi

Abstract

The authors describe the case of a 9-year-old girl who underwent liver transplantation because she suffered from severe hypoxemia caused by patent ductus venosus (PDV). Generally, severe hypoxemia (PaO2 < 50 mm Hg in room air or < 300 mm Hg in pure oxygen) is not an indication for liver transplantation because the hypoxemia may not be improved, and may lead to a fatal outcome. PDV, which is associated with mild liver dysfunction, is not an indication for liver transplantation by itself. But in our patient, most of the mesenteric venous flow directly entered the systemic circulation through the PDV just like the portosystemic shunt, and this caused the pulmonary arteriovenous shunt and hypoxemia. Thus, the authors operated on the patient in an attempt to restore her pulmonary function. Nitric oxide (10 to 20 ppm) was added to the inhaled gas to dilate the functional pulmonary capillaries and to deliver sufficient oxygen after the transplantation. Although the patient suffered various complications after the operation, the final results were excellent.

References

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Citations

May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T ChibaW Hida
Dec 25, 2003·Journal of Pediatric Surgery·Yasunori YoshimotoHiroko Tanaka
Oct 20, 2004·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Takuya KimuraMasahiro Fukuzawa
May 24, 2012·Transplantation·Seisuke SakamotoMureo Kasahara
Sep 18, 2007·Journal of Gastroenterology and Hepatology·Peter WittersDavid Cassiman
Jan 27, 2005·Journal of Paediatrics and Child Health·K M CheungA K H Chan
Jun 2, 2000·Journal of Vascular and Interventional Radiology : JVIR·J M LaBergeL M Messina
Sep 19, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Taku IidaShinji Uemoto
Apr 26, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nitika Arora GuptaRene Romero
Nov 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sukru EmreBenjamin L Shneider
Dec 28, 2007·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Mark D Stringer
Apr 15, 2003·European Journal of Pediatrics·Yoshitsugu SugioMasato Tsukahara
Feb 5, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D NayyarS Gupta
Aug 22, 2021·Respiratory Medicine and Research·Catarina Aragon PintoAlice Gallo de Moraes

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