Liver transplantation for viral hepatitis

British Medical Bulletin
J G O'Grady, R Williams

Abstract

Current one year survival rates of 73-83% for elective transplantation, and 55-70% for emergency transplantation, render liver transplantation an appropriate treatment for both end-stage chronic liver disease and acute liver failure. Candidates for transplantation for acute liver failure need to be identified as early as possible, and a model for selection using clinical criteria is described. Recurrent viral infection after transplantation is either a possible or proven problem in all patient subgroups, but the clearest manifestation is in patients with chronic hepatitis B infection. In our series of 29 patients surviving at least 60 days after transplantation, 41% died as a consequence of recurrent infection at 3-13 months. Delta virus infection appears to confer some protection in this regard, and the role of long-term immunoprophylaxis in preventing this serious complication remains to be established.

Citations

Nov 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·P Y WongR Williams
Apr 1, 1992·Genitourinary Medicine·R J Gilson
Apr 1, 1993·Digestive Diseases and Sciences·R P Perrillo
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M G GhanyA S Lok
Oct 14, 2004·Transplantation·Michael P Curry
Jan 1, 1992·International Journal of Clinical & Laboratory Research·A Smedile, M Rizzetto

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