Liver Transplantation From Controlled Donors After Circulatory Death Using Normothermic Regional Perfusion: An Initial French Experience.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Corinne AntoineFrench National Steering Committee of Donors After Circulatory Death

Abstract

A national program of controlled donation after circulatory death (cDCD) began in France in 2014 involving the use of a standardized national protocol that involves the systematic use of normothermic regional perfusion (NRP). In this article, we describe in detail the French cDCD program. Between January 1, 2015, and December 31, 2018, 225 livers were offered for donation, resulting in 123 cDCD liver transplantations (LTs). The overall 90-day graft survival rate was 93.1% (95% confidence interval [CI], 85.9%-96.6%). A total of 21 of 123 LTs (17%) did not adhere strictly to the national protocol. The 1-year graft survival was significantly lower in the group deviating from the national protocol compared with those patients following the national protocol: 68.4% (95% CI, 42.8%-84.4%) versus 94.8% (95% CI, 86.5%-98.0%; P < 0.01). There were 14 patients who died, including 2 after primary 2 after primary non function, and 10 related to liver cancer recurrence. Only 1 case of ischemic cholangiopathy was observed at month 18 in this series, and the patient underwent a successful retransplant. During the first 4 years, excellent LT results were observed where the national protocol was followed. Systematic use of NRP limits liver damag...Continue Reading

References

Oct 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A K MathurR M Merion
Jul 4, 2012·Gastroenterology·Christophe DuvouxUNKNOWN Liver Transplantation French Study Group
Jan 7, 2014·Annales Françaises D'anesthèsie Et De Rèanimation·C AntoineUNKNOWN Steering committee on DCD program
Oct 7, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G C OniscuC J E Watson
Apr 14, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eric SavierUNKNOWN Donation After Cardiac Death Study Group
Mar 19, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·M ThuongR J Ploeg
Dec 28, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christopher J E WatsonGabriel C Oniscu
Apr 16, 2019·Transplantation·Corinne AntoineUNKNOWN National Steering Committee of Donation After Circulatory Death

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Citations

Jul 24, 2021·Nature Communications·Chris J C JohnstonGabriel C Oniscu
Aug 8, 2021·International Journal of Molecular Sciences·Łukasz Masior, Michał Grąt
Aug 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Xavier MullerJean-Yves Mabrut
Sep 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Julie De BeuleIna Jochmans
Oct 11, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Xavier MullerJean-Yves Mabrut

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