Liver transplantation in elderly patients: a systematic review and first meta-analysis

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Concepción Gómez GavaraDaniel Azoulay

Abstract

Elderly recipients are frequently discussed by the scientific community but objective indication for this parameter has been provided. The aim of this study was to synthesize the available evidence on liver transplantation for elderly patients to assess graft and patient survival. A literature search of the Medline, EMBASE, and Scopus databases was carried out from January 2000 to August 2018. Clinical studies comparing the outcomes of liver transplantation in adult younger (<65 years) and elderly (>65 years) populations were analyzed. The primary outcomes were patient mortality and graft loss rates. This review was registered (Number CRD42017058261) as required in the international prospective register for systematic review protocols (PROSPERO). Twenty-two studies were included involving a total of 242,487 patients (elderly: 23,660 and young: 218,827) were included in this study. In the meta-analysis, the elderly group had patient mortality (hazard ratio [HR]: 1.26; 95% confidence interval [CI]: 0.97-1.63; P = 0.09; I2 = 48%) and graft (HR: 1.09; 95% CI: 0.81-1.47; P = 0.59; I2 = 12%) loss rates comparable to those in the young group. Elderly patients have similar long-term survival and graft loss rates as young patients. Live...Continue Reading

Citations

Jun 25, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Omar Y MousaDenise M Harnois
Apr 13, 2020·Surgery Today·Shimon DolnikovMarc Antoine Allard
Sep 10, 2020·Annals of Surgical Oncology·Jaynee J A VugtsStefan Buettner
Sep 12, 2019·Clinical Liver Disease·Lamia HaqueJennifer Batisti
Sep 12, 2019·Clinical Liver Disease·Avash KalraJ P Norvell
Oct 1, 2020·World Journal of Transplantation·Danko Mikulic, Anna Mrzljak
Feb 19, 2021·Expert Review of Gastroenterology & Hepatology·Eric S OrmanGreg A Sachs
Feb 23, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nabeel A WahidRobert S Brown
Apr 1, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Abdul Rahman HakeemMohamed Rela
Aug 11, 2021·Current Opinion in Organ Transplantation·Fabio MelandroDavide Ghinolfi

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