Liver transplantation in HIV-positive patients

Clinical Transplantation
Christoph EisenbachJens Encke

Abstract

Death from end-stage liver disease (ESLD) because of chronic hepatitis B and C has become an increasing problem in human immunodeficiency virus (HIV)-infected patients in the last years. This is mainly because of the dramatic decrease of HIV-related morbidity and mortality since the introduction of highly active antiretroviral therapy (HAART). Although the data on the outcome of liver transplantation in HIV-infected recipients with ESLD is limited, overall results seem comparable to non-HIV-infected recipients. Therefore, liver transplant centres around the world are increasingly accepting HIV-infected individuals as organ recipients. Post-transplantation control of HIV replication is achieved by continuing HAART. As in non-HIV-infected patients, hepatitis B virus recurrence is efficiently prevented by hepatitis B immunoglobulin and antiviral therapy. Re-infection of the allograft with hepatitis C virus, however, remains an important problem, and progress to allograft cirrhosis may even be more rapid than in HIV-negative patients. Interactions in drug metabolism between the HAART components and the immunosuppressive drugs are difficult to predict and require close monitoring of drug levels and dose adjustments. The complexity i...Continue Reading

References

Feb 1, 1990·Transplantation·A G TzakisT E Starzl
Apr 1, 1988·Transplant International : Official Journal of the European Society for Organ Transplantation·R H Rubin, N E Tolkoff-Rubin
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Nov 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F BouscaratA G Saimot
Nov 22, 2000·The Journal of Infectious Diseases·M PuotiUNKNOWN HIV-HCV Coinfection Study Group
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I BicaD R Snydman
Dec 1, 2001·Transplantation·A A PrachaliasN D Heaton
Feb 8, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth E ShermanNatasa Rajicic
Jul 26, 2002·The New England Journal of Medicine·Scott D HalpernArthur L Caplan
Aug 30, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ashok Kumar B JainJohn J Fung
Dec 21, 2002·Lancet·Chloe L ThioUNKNOWN Multicenter AIDS Cohort Study
Feb 1, 2003·Annals of Internal Medicine·Mark S Sulkowski, David L Thomas
Mar 6, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Guy W NeffJohn J Fung
Jun 6, 2003·The New England Journal of Medicine·Michelle E Roland, Diane V Havlir
Jul 16, 2003·The Journal of Infection·Bernardino RocaTrinitario Sánchez
Aug 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·A HerediaR R Redfield
Nov 15, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ronald B ReislerJames D Neaton
Nov 19, 2003·The Journal of Infectious Diseases·Margaret V RagniJohn F Fung
Dec 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luz Martín-CarboneroVincent Soriano
Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maurizio Bonacini
Jul 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Martin VogelUlrich Spengler
Jul 16, 2004·Kidney International·Hassane IzzedineGilbert Deray
Sep 18, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Antonio RafecasTeresa Serrano
Sep 18, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Suzanne NorrisJohn G O'Grady
Jan 5, 2005·Journal of Hepatology·René AdamVincent Karam
Feb 4, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Santiago MorenoAdolfo Martínez
Feb 9, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Klaus RadeckeUlrich Treichel
Apr 1, 2005·The New England Journal of Medicine·Giovanni StalloneGiuseppe Grandaliano
Apr 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan A PinedaUNKNOWN Grupo Andaluz para el Estudio del Hígado
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Scott D HalpernEmily Blumberg
Jun 24, 2005·Journal of Hepatology·Dominique Salmon-CeronUNKNOWN Mortality 2000 study group

❮ Previous
Next ❯

Citations

May 31, 2011·Transplantation Proceedings·F Di BenedettoG E Gerunda
Dec 12, 2018·The Journal of Trauma and Acute Care Surgery·Britt J SandlerKevin M Schuster
Jul 20, 2010·European Journal of Clinical Investigation·Minoru TanabeMasaki Kitajima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
J FungM Ragni
World Journal of Gastroenterology : WJG
Ashwani-K Singal, Bhupinderjit S Anand
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
M E de VeraM Ragni
© 2022 Meta ULC. All rights reserved