Liver transplantation-induced antihistone H1 autoantibodies suppress mixed lymphocyte reaction

Transplantation
Toshiaki NakanoK Ono

Abstract

In a rat model of orthotopic liver transplantation (OLT), recipient serum after OLT (post-OLT serum) has been reported to prevent allograft rejection. However, the molecular identities of immunosuppressive factors, which are in the early stage of post-OLT, remain elusive. This study was aimed to identify immunodominant suppressive factors present in early post-OLT serum. The immunosuppressive activities of post-OLT serum, immunoglobulin (Ig) G-depleted serum, and purified IgG were evaluated in vitro by inhibition of the mixed lymphocyte reaction (MLR). Autoantigens recognized by the MLR-inhibitory IgG in early post-OLT serum were identified by the internal protein sequencing. Recipient post-OLT serum inhibited MLR, and its immunosuppressive activity vanished by means of the elimination of OLT-inducible IgG. IgG from post-OLT sera (2-3 weeks) specifically reacted to 31-, 34-, and 73-kDa autoantigens on splenic cells. The internal sequences of the doublet 31- and 34-kDa antigens coincided completely with those of histone H1 molecules. The levels of histone H1-specific antibodies were transiently increased to a plateau around 2 to 3 weeks after OLT but decreased in the later tolerogenic phase. Immunodepletion of antihistone H1 aut...Continue Reading

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Citations

Apr 15, 2005·Molecular Immunology·Li-Wen HsuChao-Long Chen
Aug 12, 2009·Hybridoma·Gnanasekaran PrabuVasanthi Nachiappan
Apr 25, 2007·Transplantation·Toshiaki NakanoChao-Long Chen
Jul 25, 2007·Journal of Gastroenterology and Hepatology·Yu-Chun LinKatsutoshi Yoshizato
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Missag H Parseghian, Keith A Luhrs
May 22, 2013·Clinical & Developmental Immunology·Toshiaki NakanoShigeru Goto
May 28, 2008·Transplant Immunology·Toshiaki NakanoChao-Long Chen
Dec 19, 2006·Transplantation Proceedings·T NakanoC-L Chen
Feb 20, 2007·Transplant Immunology·Toshiaki NakanoYu-Fan Cheng
Dec 15, 2005·Neurochemistry International·Sudarshan C UpadhyaAshok N Hegde
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kuei-Chen ChiangShuji Sato

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