Abstract
Until recently, human immunodeficiency virus (HIV) infection was considered an absolute contraindication for liver transplantation in Spain. We present the first 4 cases of liver transplantation (LT) carried out in our center in patients infected with HIV and coinfected by the hepatitis C virus (HCV), immunosuppressed with cyclosporine A (CyA) and basiliximab, but without steroids. The 4 patients were male, with a mean age of 38.25 +/- 4.5 years. Mean time of HIV infection was 114 +/- 62.3 months and all patients were receiving highly active antiretroviral therapy (HAART). HCV genotypes of the 4 patients were 4, 1b, 1b, and 1a. Two patients were classified as Child-Turcotte-Pugh C (10 and 11 points), 1 was B (8 points), and the patient with hepatocellular carcinoma was A (5 points). Immunosuppression consisted of basiliximab and monotherapy with CyA. There were no postoperative infections. With a follow-up of 17 +/- 8 months, all patients are alive. There was only 1 acute rejection episode, and this was solved with steroid pulses. Three patients showed HCV recurrence with enzymatic and histological changes and were treated with interferon and ribavirin. One patient had negative HCV-ribonucleic acid after 6 months of treatment. ...Continue Reading
References
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A KarpasF Hill
Feb 1, 1990·Transplantation·A G TzakisT E Starzl
Mar 27, 1998·The New England Journal of Medicine·F J PalellaS D Holmberg
Aug 8, 1998·The New England Journal of Medicine·S H MichaelsP Kissinger
Aug 10, 1999·Transplantation·A M SheikhH W Horowitz
Jul 11, 2000·Nature Medicine·A G ChapuisG Pantaleo
Aug 19, 2000·Transplantation·R Reding
Aug 31, 2000·Medicina clínica·J Castilla, L de la Fuente
Mar 27, 2001·Transplantation Proceedings·J A Fishman, R H Rubin
Oct 27, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J FiguerasA Dalmau
Dec 1, 2001·Transplantation·A A PrachaliasN D Heaton
Dec 26, 2001·Transplantation Proceedings·P StockN Ascher
Apr 20, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jeffrey S CrippinMichael R Charlton
May 23, 2002·Transplantation·Gary LevyUNKNOWN Consensus on Neoral C(2): Expert Review in Transplantation (CONCERT) Group
Aug 30, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Laura LladóEduardo Jaurrieta
Aug 30, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ashok Kumar B JainJohn J Fung
Feb 28, 2003·Transplantation·Michelle E Roland, Peter G Stock
Jun 25, 2003·Journal of Hepatology·Didier SamuelDaniel Vittecoq
Jul 29, 2003·Transplantation·Peter G StockNancy L Ascher
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John R Lake
Nov 19, 2003·The Journal of Infectious Diseases·Margaret V RagniJohn F Fung
Dec 5, 2003·Lancet·Michail S Lionakis, Dimitrios P Kontoyiannis
Dec 6, 2003·Transplantation·Kapil B ChopraHugo E Vargas
Dec 31, 2003·Lancet·Raymond RedingHugh F S Davies
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Calogero CammàAntonio Craxì
Citations
Sep 15, 2006·Current HIV/AIDS Reports·Michelle E Roland, Peter G Stock
Sep 17, 2011·Surgery Today·Susumu EguchiTakashi Kanematsu
Apr 2, 2008·Current Infectious Disease Reports·Pierluigi VialeMarcello Tavio
Aug 9, 2006·Current Opinion in Oncology·Liron PantanowitzBruce J Dezube
Feb 14, 2007·Transplantation·Lluis CastellsCarlos Margarit
Mar 18, 2011·AIDS·Curtis CooperEdward J Mills
Aug 5, 2011·European Journal of Medical Research·S VernadakisZ Mathé
Mar 12, 2011·World Journal of Gastrointestinal Surgery·Yasuhiko SugawaraNorihiro Kokudo
Apr 7, 2010·Gastroenterología y hepatología·Lourdes Rafael-ValdiviaAntoni Rimola
Dec 15, 2015·Clinical Journal of Gastroenterology·Harufumi MakiNorihiro Kokudo
Dec 1, 2004·Alimentary Pharmacology & Therapeutics·G W NeffJ Fung
Jun 26, 2009·Reviews in Medical Virology·Shirish Huprikar
Dec 16, 2009·Clinical Transplantation·Christoph EisenbachJens Encke
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Suzanne NorrisDiarmaid Houlihan
Jun 23, 2005·Enfermedades infecciosas y microbiología clínica·José M MiróBlanca Miranda