Liver tryptophan pyrrolase. A major determinant of the lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL mice.

The Biochemical Journal
A A BadawyD M Bradley

Abstract

The lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL, compared with -non-preferring CBA, mice is caused by a decrease in circulating tryptophan availability to the brain secondarily to a higher liver tryptophan pyrrolase activity associated with a higher circulating corticosterone concentration. Activity or expression of liver tryptophan pyrrolase and/or their induction by glucocorticoids may be important biological determinants of predisposition to alcohol consumption.

Citations

Jan 8, 2008·Journal of Affective Disorders·Richard J PorterMartin Kennedy
Jun 1, 2002·Nutrition Research Reviews·Abdulla A-B Badawy
Aug 8, 2013·International Journal of Tryptophan Research : IJTR·Akihiro MaetaKatsumi Shibata
Aug 12, 2014·Obstetrics & Gynecology Science·Abdulla A-B Badawy
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·F Chen, A J Lawrence
Sep 8, 2000·Bulletin of Experimental Biology and Medicine·E D Vasil'evaG V Vasil'ev
Jan 1, 1990·Annals of Medicine·M Virkkunen, M Linnoila
Sep 19, 2015·Bioscience Reports·Abdulla A-B Badawy
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M YoshinoY Shibata
Sep 15, 1994·Biological Psychiatry·D LeMarquandC Benkelfat

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