Liver Tumor Burden in Pancreatic Neuroendocrine Tumors: CT Features and Texture Analysis in the Prediction of Tumor Grade and 18 F-FDG Uptake

Cancers
Alessandro BeleùMirko D'Onofrio

Abstract

Pancreatic neuroendocrine tumors (p-NETs) are a rare group of neoplasms that often present with liver metastases. Histological characteristics, metabolic behavior, and liver tumor burden (LTB) are important prognostic factors. In this study, the usefulness of texture analysis of liver metastases in evaluating the biological aggressiveness of p-NETs was assessed. Fifty-six patients with liver metastases from p-NET were retrospectively enrolled. Qualitative and quantitative CT features of LTB were evaluated. Histogram-derived parameters of liver metastases were calculated and correlated with the tumor grade (G) and 18F-fluorodeoxyglucose (18F-FDG) standardized uptake value (SUV). Arterial relative enhancement was inversely related with G (-0.37, p = 0.006). Different metastatic spread patterns of LTB were not associated with histological grade. Arterialentropy was significantly correlated to G (-0.368, p = 0.038) and to Ki67 percentage (-0.421, p = 0.018). The ROC curve for the Arterialentropy reported an area under the curve (AUC) of 0.736 (95% confidence interval 0.545-0.928, p = 0.035) in the identification of G1-2 tumors. Arterialuniformity values were correlated to G (0.346, p = 0.005) and Ki67 levels (0.383, p = 0.033). Art...Continue Reading

References

Jul 8, 2008·Endocrine-related Cancer·Ulrich-Frank PapeBertram Wiedenmann
Jan 23, 2009·The British Journal of Surgery·A FrillingC E Broelsch
Mar 23, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Aldo ScarpaMassimo Falconi
Oct 25, 2012·Insights Into Imaging·Fergus DavnallVicky Goh
Sep 3, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·David J WorhunskyGeorge A Poultsides
Jan 5, 2014·The Lancet Oncology·Andrea FrillingUNKNOWN Working Group on Neuroendocrine Liver Metastases
May 31, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Samer EzziddinJames Nagarajah
Oct 1, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Claudio RicciFrancesco Minni
Oct 8, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Haïfa BahriEtienne Garin
Feb 25, 2017·The Oncologist·Francesco PanzutoGianfranco Delle Fave
Aug 9, 2017·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Giulia A ZamboniRoberto Pozzi Mucelli
Nov 16, 2017·AJR. American Journal of Roentgenology·Rodrigo CanellasDushyant V Sahani
Jan 21, 2018·European Radiology·Riccardo De RobertisMirko D'Onofrio
Jan 11, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jooae ChoeNikhil Ramaiya
Feb 20, 2019·Scientific Reports·Mirko D'OnofrioAldo Scarpa

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Methods Mentioned

BETA
biopsy
biopsies
replace
a

Software Mentioned

LIFEx
SPSS Statistic

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