Liver x receptor signaling pathways and atherosclerosis.

Arteriosclerosis, Thrombosis, and Vascular Biology
Anna C Calkin, Peter Tontonoz

Abstract

First discovered as orphan receptors, liver X receptors (LXRs) were subsequently identified as the nuclear receptor target of the cholesterol metabolites, oxysterols. There are 2 LXR receptors encoded by distinct genes: LXRalpha is most highly expressed in the liver, adipose, kidney, adrenal tissues, and macrophages and LXRbeta is ubiquitously expressed. Despite differential tissue distribution, these isoforms have 78% homology in their ligand-binding domain and appear to respond to the same endogenous ligands. Work over the past 10 years has shown that the LXR pathway regulates lipid metabolism and inflammation via both the induction and repression of target genes. Given the importance of cholesterol regulation and inflammation in the development of cardiovascular disease, it is not surprising that activation of the LXR pathway attenuates various mechanisms underlying atherosclerotic plaque development. In this brief review, we will discuss the impact of the LXR pathway on both cholesterol metabolism and atherosclerosis.

References

May 1, 1994·The Journal of Clinical Investigation·K E WatsonL L Demer
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·A VenkateswaranP Tontonoz
Mar 10, 2001·Cell·C K Glass, J L Witztum
Jan 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Hailing LiaoYi Zhu
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sean B JosephPeter Tontonoz
Aug 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Rajendra K TangiralaIra G Schulman
Aug 28, 2002·Circulation·Gertrud U SchusterJan-Ake Gustafsson
Jan 14, 2003·Nature Medicine·Sean B JosephPeter Tontonoz
Jan 18, 2003·The Journal of Biological Chemistry·Antonio CastrilloPeter Tontonoz
Nov 13, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nancy LevinIra G Schulman
Jul 28, 2007·The Journal of Clinical Investigation·Michelle N BradleyPeter Tontonoz
Dec 22, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Minjia ZhuYi Zhu
Apr 26, 2008·Journal of Cardiovascular Pharmacology·Xiao-Yan DaiChao-Ke Tang
May 10, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Hafid Ait-OufellaZiad Mallat
Jun 5, 2008·American Journal of Physiology. Endocrinology and Metabolism·Andreas PeterErwin Schleicher
Jul 8, 2008·Journal of Atherosclerosis and Thrombosis·Eiji SaitoYoshiyuki Seyama
Sep 13, 2008·Science in China. Series C, Life Sciences·Xiang OuChaoKe Tang
Sep 13, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Daniel TeupserJoachim Thiery
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshikazu NaikiMoshe Arditi
Mar 31, 2009·FEBS Letters·Jeffrey J HsuYin Tintut
Sep 16, 2009·Annals of the New York Academy of Sciences·Ira TabasWahseng Lim

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Citations

Aug 28, 2012·Pharmaceutical Research·Stephen D LeeKishor M Wasan
Apr 18, 2013·Current Atherosclerosis Reports·Julian C van CapelleveenJohn J P Kastelein
Nov 21, 2013·Trends in Endocrinology and Metabolism : TEM·Abdoulaye Sene, Rajendra S Apte
Jul 21, 2012·Current Opinion in Lipidology·Vesa M Olkkonen
Jan 24, 2013·Current Opinion in Lipidology·Elizabeth J Tarling
Jan 12, 2013·Science·Ira Tabas, Christopher K Glass
May 12, 2012·Mediators of Inflammation·Ting GuiYasuteru Muragaki
Mar 3, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Godfrey S Getz, Catherine A Reardon
Apr 16, 2011·Circulation Research·Seung-Soon Im, Timothy F Osborne
Jul 16, 2011·Circulation Research·Benoit PourcetInés Pineda-Torra
Apr 10, 2012·The Journal of Clinical Investigation·Yuan ZhangIra G Schulman
Oct 15, 2013·Respiratory Research·Andrew HighamDave Singh
Aug 24, 2013·Journal of Translational Medicine·Nehal N MehtaCarrie Brodmerkel
Aug 13, 2013·PLoS Computational Biology·Christian A TiemannNatal A W van Riel
Oct 23, 2012·Journal of the American Society of Nephrology : JASN·Hiromi TachibanaHirofumi Makino
Apr 22, 2014·Vascular Health and Risk Management·Bishnu H SubediErin D Michos
Oct 26, 2013·CNS Oncology·Deliang GuoArnab Chakravarti
Apr 10, 2014·The Journal of Clinical Investigation·Inna AstapovaAnthony N Hollenberg
May 1, 2012·Annual Review of Nutrition·Xuewei Zhu, John S Parks
Nov 14, 2013·Seminars in Liver Disease·Xu XuAnn-Hwee Lee
Nov 28, 2015·Basic Research in Cardiology·Megan V CannonRudolf A de Boer
Jan 10, 2013·Clinical Science·Anne Marie AllenAnnette Graham
Sep 5, 2013·Free Radical Research·G ServiddioG Vendemiale
Jul 2, 2011·Expert Opinion on Therapeutic Targets·Shweta Mandrekar-Colucci, Gary E Landreth
Jun 15, 2012·Molecular Membrane Biology·Magnus BentingerSergiu-Bogdan Catrina
Feb 13, 2015·International Journal of Molecular Medicine·Sin-Hye ParkYoung-Hee Kang
Jul 30, 2014·Frontiers in Aging Neuroscience·Kaushal SharmaAkshay Anand
May 28, 2016·Lipids in Health and Disease·Bo ZhangHao Zhang
Jun 13, 2015·Experimental Biology and Medicine·Meng YangHaiping Wang
Jan 7, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Vesa M OlkkonenElina Ikonen
May 27, 2017·Vision Research·Sandra S Hammer, Julia V Busik
Mar 29, 2014·Journal of Lipid Research·Tamer SallamCynthia Hong

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