Liver X receptors as integrators of metabolic and inflammatory signaling

The Journal of Clinical Investigation
Noam Zelcer, Peter Tontonoz

Abstract

The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that are activated in response to elevated intracellular cholesterol levels in multiple cell types. Once activated, LXRs induce the expression of an array of genes involved in cholesterol absorption, efflux, transport, and excretion. In addition to their function in lipid metabolism, LXRs have also been found to modulate immune and inflammatory responses in macrophages. Synthetic LXR agonists promote cholesterol efflux and inhibit inflammation in vivo and inhibit the development of atherosclerosis in animal models. The ability of LXRs to integrate metabolic and inflammatory signaling makes them particularly attractive targets for intervention in human metabolic disease.

References

May 1, 1995·Genes & Development·P J WillyD J Mangelsdorf
Feb 7, 1997·The Journal of Biological Chemistry·J M LehmannT M Willson
Sep 16, 1998·Current Opinion in Chemical Biology·J A Gustafsson
Jun 16, 1999·Endocrine Reviews·N J McKennaB W O'Malley
Oct 28, 1999·American Heart Journal·G I Byrne, M V Kalayoglu
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·J KluckenG Schmitz
Feb 23, 2000·The Journal of Clinical Investigation·Y Luo, A R Tall
Jun 20, 2000·The Journal of Biological Chemistry·P CostetA R Tall
Jul 6, 2000·Current Opinion in Lipidology·L K Curtiss, W A Boisvert
Aug 5, 2000·Biochemical and Biophysical Research Communications·K SchwartzD P Wade
Sep 23, 2000·Nature·A J Lusis
Oct 14, 2000·Annual Review of Cell and Developmental Biology·J J Repa, D J Mangelsdorf
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·A VenkateswaranP Tontonoz
Nov 23, 2000·Genes & Development·J R SchultzB Shan
Jan 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·B A LaffitteP Tontonoz
Feb 13, 2001·Atherosclerosis·C M ShanahanN R Cary
Mar 10, 2001·The Journal of Clinical Investigation·S AlbertiJ A Gustafsson
Mar 10, 2001·Cell·C K Glass, J L Witztum
Mar 27, 2001·Current Opinion in Lipidology·M H LeeS B Patel
Aug 16, 2001·The Journal of Biological Chemistry·X FuE G Lund
Sep 8, 2001·The Journal of Biological Chemistry·K D WhitneyS A Kliewer
Oct 18, 2001·Molecular and Cellular Biology·B A LaffitteP Tontonoz
Oct 19, 2001·Biochemical and Biophysical Research Communications·T EngelG Assmann
Dec 1, 2001·Science·A ChawlaD J Mangelsdorf
Jan 16, 2002·The Journal of Biological Chemistry·Sean B JosephPeter Tontonoz
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Mar 20, 2002·The Journal of Biological Chemistry·Joyce J RepaDavid J Mangelsdorf
Apr 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert J AielloOmar L Francone
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Miranda van EckGerd Schmitz
May 8, 2002·The Journal of Clinical Investigation·Jay D HortonMichael S Brown
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sean B JosephPeter Tontonoz
Jun 5, 2002·Annual Review of Biochemistry·P Borst, R Oude Elferink

❮ Previous
Next ❯

Citations

Jan 14, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Youngki ParkJiyoung Lee
Mar 29, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey M Saland, Henry N Ginsberg
Mar 21, 2007·Journal of Biomedical Science·Chih-Pin ChuuShutsung Liao
Feb 5, 2008·Current Atherosclerosis Reports·Luis VillacortaYuqing E Chen
Mar 28, 2008·Current Atherosclerosis Reports·Takashi Nomiyama, Dennis Bruemmer
Oct 14, 2008·Genes & Nutrition·C Martini, V Pallottini
Oct 14, 2008·Genes & Nutrition·Fiorella BiasiGiuseppe Poli
Oct 15, 2010·Archives of Pharmacal Research·Il HongMi-Ock Lee
Jul 11, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kiran Lata SharmaBalraj Mittal
Apr 30, 2013·Molecular and Cellular Endocrinology·Yurii ChinenovInez Rogatsky
Nov 28, 2006·Nature Reviews. Cancer·Daniel W Nebert, Timothy P Dalton
Mar 15, 2012·Nature Reviews. Molecular Cell Biology·Anna C Calkin, Peter Tontonoz
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·Veerle Rottiers, Anders M Näär
Sep 7, 2011·Nature Reviews. Neurology·Joanna M Karasinska, Michael R Hayden
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiaotang FanJan-Ake Gustafsson
Sep 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chiara GabbiJan-Ake Gustafsson
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ning LiZhiyong Yang
May 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Vanessa NúñezMercedes Ricote
Sep 29, 2009·The Journal of Biological Chemistry·Chongren TangJohn F Oram
Aug 5, 2008·The Journal of Biological Chemistry·Yongjun WangThomas P Burris
Oct 20, 2006·Molecular Biology of the Cell·Matts D LinderElina Ikonen
Jul 3, 2013·Briefings in Functional Genomics·Marta Simonatto, Gioacchino Natoli
Mar 1, 2008·European Heart Journal·David E LaaksonenJukka T Salonen
Jul 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jia ShaoOscar L Volger
Feb 7, 2007·Current Opinion in Rheumatology·Tohru AkahoshiHidero Kitasato
Oct 30, 2008·Current Opinion in Lipidology·Mohammed Mahmood Hussain, Ahmed Bakillah
Jan 20, 2011·Genes & Development·Gioacchino NatoliIros Barozzi
Jan 30, 2009·Diabetes, Obesity & Metabolism·K C B Tan
Jan 26, 2011·Infection and Immunity·Tie ZouVictor L Boyartchuk

❮ Previous
Next ❯

Methods Mentioned

BETA
sumoylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.