Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology

Biochemical and Biophysical Research Communications
Abdelkader OumeddourJean-Marc A Lobaccaro

Abstract

Liver X receptors LXRα (NR1H3) and LXRβ (NR1H2) are transcription factors belonging to the nuclear receptor superfamily, activated by specific oxysterols, oxidized derivatives of cholesterol. These receptors are involved in the regulation of testis physiology. Lxr-deficient mice pointed to the physiological roles of these nuclear receptors in steroid synthesis, lipid homeostasis and germ cell apoptosis and proliferation. Diethylstilbestrol (DES) is a synthetic estrogen considered as an endocrine disruptor that affects the functions of the testis. Various lines of evidences have made a clear link between estrogens, their nuclear receptors ERα (NR3A1) and ERβ (NR3A2), and Lxrα/β. As LXR activity could also be regulated by the nuclear receptor small heterodimer partner (SHP, NR0A2) and DES could act through SHP, we wondered whether LXR could be targeted by estrogen-like endocrine disruptors such as DES. For that purpose, wild-type and Lxr-deficient mice were daily treated with 0.75 μg DES from days 1 to 5 after birth. The effects of DES were investigated at 10 or 45 days of age. We demonstrated that DES induced a decrease of the body mass at 10 days only in the Lxr-deficient mice suggesting a protective effect of Lxr. We defined t...Continue Reading

References

May 1, 1995·Genes & Development·P J WillyD J Mangelsdorf
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·C SongS Liao
Oct 31, 1998·Current Opinion in Genetics & Development·D J PeetD J Mangelsdorf
Mar 12, 2005·Endocrinology·Kirsten M RobertsonJan-Ake Gustafsson
Mar 9, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Katrine BayAnna-Maria Andersson
Dec 15, 2006·The Journal of Biological Chemistry·Kevin MouzatJean-Marc A Lobaccaro
Mar 8, 2007·Molecular Endocrinology·David H VolleJean-Marc A Lobaccaro
Jan 27, 2009·Carcinogenesis·Lise-Lotte VedinKnut R Steffensen
Feb 19, 2009·Clinical Endocrinology·Christine Wohlfahrt-VejeNiels Erik Skakkebaek
Nov 4, 2009·The Journal of Clinical Investigation·David H VolleMohamed Benahmed
Jan 6, 2011·Expert Opinion on Therapeutic Targets·Emilie ViennoisJean-Marc A Lobaccaro
Sep 13, 2011·Molecular and Cellular Endocrinology·Emilie ViennoisSilvère Baron
Dec 1, 2011·Molecular and Cellular Endocrinology·Helena E Virtanen, Annika Adamsson
Apr 10, 2013·American Journal of Epidemiology·Tina Kold JensenNiels Jørgensen
Jul 23, 2013·The Journal of Clinical Investigation·Tomonori IshikawaMichihisa Umetani

❮ Previous
Next ❯

Citations

Apr 20, 2016·Molecular Aspects of Medicine·Salwan MaqdasyJean-Marc A Lobaccaro
May 23, 2015·Frontiers in Endocrinology·Virginie Rouiller-FabreGabriel Livera
Apr 4, 2021·Aquatic Toxicology·Keng Po LaiWilliam Ka Fai Tse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis