PMID: 16503873Mar 1, 2006Paper

Liver x receptors: potential novel targets in cardiovascular diseases

Current Drug Targets. Cardiovascular & Haematological Disorders
Dennis Bruemmer, Ronald E Law

Abstract

The Liver X Receptors, LXRalpha and LXRbeta are members of the nuclear hormone receptor superfamily which have recently been implicated as novel pharmacological targets for the treatment of cardiovascular diseases. The identification of natural and synthetic ligands for LXRs and the generation of LXR-deficient mice have been crucial for our understanding of the function of these receptors and for the identification of LXR-regulated target genes, particularly with respect to the role of LXRs in regulating cholesterol homeostasis. Synthetic LXRalpha/beta agonists induce cholesterol efflux and reverse cholesterol transport, improve glucose metabolism, inhibit macrophage-derived inflammation, and suppress the proliferation of vascular smooth muscle cells. By regulating the expression of multiple genes involved in these pathways, LXR agonists prevent the development and progression of atherosclerosis and inhibit neointima formation following angioplasty of the arterial wall. In this review, we will summarize the important roles of LXR in metabolism and vascular biology and discuss its implications as potential molecular drug target for the treatment of cardiovascular diseases.

Citations

Jul 17, 2008·Vascular Health and Risk Management·Navin K KapurRoger S Blumenthal
Aug 14, 2009·Archives of Physiology and Biochemistry·Sonia Fernández-VeledoMargarita Lorenzo
Jun 6, 2012·Molecular and Cellular Endocrinology·Kondababu KurakulaCarlie J M de Vries
Sep 13, 2008·Science in China. Series C, Life Sciences·Xiang OuChaoKe Tang
Jul 1, 2010·European Journal of Heart Failure·Irma KuipersRudolf A de Boer
Feb 24, 2009·Current Opinion in Pharmacology·Prakash SahaAlberto Smith
Nov 16, 2007·Medicinal Research Reviews·R L TiwariM K Barthwal

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