Livestock-Associated Methicillin Resistant and Methicillin Susceptible Staphylococcus aureus Sequence Type (CC)1 in European Farmed Animals: High Genetic Relatedness of Isolates from Italian Cattle Herds and Humans

PloS One
Patricia AlbaAntonio Battisti

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) Sequence Type (ST)1, Clonal Complex(CC)1, SCCmec V is one of the major Livestock-Associated (LA-) lineages in pig farming industry in Italy and is associated with pigs in other European countries. Recently, it has been increasingly detected in Italian dairy cattle herds. The aim of this study was to analyse the differences between ST1 MRSA and methicillin-susceptible S. aureus (MSSA) from cattle and pig herds in Italy and Europe and human isolates. Sixty-tree animal isolates from different holdings and 20 human isolates were characterized by pulsed-field gel electrophoresis (PFGE), spa-typing, SCCmec typing, and by micro-array analysis for several virulence, antimicrobial resistance, and strain/host-specific marker genes. Three major PFGE clusters were detected. The bovine isolates shared a high (≥90% to 100%) similarity with human isolates and carried the same SCCmec type IVa. They often showed genetic features typical of human adaptation or present in human-associated CC1: Immune evasion cluster (IEC) genes sak and scn, or sea; sat and aphA3-mediated aminoglycoside resistance. Contrary, typical markers of porcine origin in Italy and Spain, like erm(A) mediated macrolide-linco...Continue Reading

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Citations

Dec 20, 2016·PloS One·Stefan MoneckeRalf Ehricht
Apr 21, 2018·Journal of Medical Microbiology·Hidemasa NakaminamiNorihisa Noguchi
Jul 28, 2019·Open Medicine·Yong LuoNingwen Tang
Mar 25, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Emily C DeasyAnna C Shore
Oct 16, 2016·Cold Spring Harbor Perspectives in Medicine·Susanne Paukner, Rosemarie Riedl
Aug 23, 2019·Foodborne Pathogens and Disease·Arne Schnitt, Bernd-Alois Tenhagen
Jul 3, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Stefan MoneckeRalf Ehricht
Sep 3, 2020·EFSA Journal·UNKNOWN European Food Safety Authority, UNKNOWN European Centre for Disease Prevention and Control
Jun 8, 2017·Antibiotics·Maria Angeles ArgudínSandrine Roisin
Jan 1, 2015·Antibiotics·Christiane CunyWolfgang Witte
Sep 14, 2018·Clinical Microbiology Reviews·Sahreena Lakhundi, Kunyan Zhang
Feb 12, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Simona ZoppiAntonio Battisti
Aug 11, 2020·International Journal of Food Microbiology·Paola TomaoPaolo Visca
Apr 20, 2021·EFSA Journal·UNKNOWN European Food Safety Authority, UNKNOWN European Centre for Disease Prevention and Control
Jul 29, 2021·Scientific Reports·Madhavi AnnamanediNagendra R Hegde

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Methods Mentioned

BETA
electrophoresis
PCR
PCRs
genotyping
IEC

Software Mentioned

BioNumerics
StatCalc
Epi

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