Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones

Gerontology
Richard L Bowen, C S Atwood

Abstract

A mechanistic understanding of aging has yet to be described; this paper puts forth a new theory that has the potential to explain aging in all sexually reproductive life forms. The theory also puts forth a new definition of aging - any change in an organism over time. This definition includes not only the changes associated with the loss of function (i.e. senescence, the commonly accepted definition of aging), but also the changes associated with the gain of function (growth and development). Using this definition, the rate of aging would be synonymous with the rate of change. The rate of change/aging is most rapid during the fetal period when organisms develop from a single cell at conception to a multicellular organism at birth. Therefore, 'fetal aging' would be determined by factors regulating the rate of mitogenesis, differentiation, and cell death. We suggest that these factors also are responsible for regulating aging throughout life. Thus, whatever controls mitogenesis, differentiation and cell death must also control aging. Since life-extending modalities consistently affect reproduction, and reproductive hormones are known to regulate mitogenesis and differentiation, we propose that aging is primarily regulated by the...Continue Reading

Citations

Dec 6, 2011·Age·James A YonkerCraig S Atwood
Jun 29, 2012·European Journal of Human Genetics : EJHG·Valerio CostaAlfredo Ciccodicola
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Robert E Ricklefs
Sep 24, 2009·BMC Bioinformatics·Jesse Gillis, Paul Pavlidis
Jun 2, 2015·Pakistan Journal of Biological Sciences : PJBS·Ghazi DaradkehMostafa I Waly
Nov 1, 2007·Expert Opinion on Investigational Drugs·Andrea C WilsonCraig S Atwood
Feb 6, 2016·Age·Magdalena Jura, Leslie P Kozak
Sep 21, 2010·Experimental Gerontology·Craig S Atwood, Richard L Bowen
Nov 5, 2008·Clinical Neurology and Neurosurgery·Yuichi HirotaYutaka Hayashi
Apr 1, 2008·Ageing Research Reviews·Craig S Atwood, Richard L Bowen
May 15, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·João Pedro de Magalhães, Richard G A Faragher
Jun 4, 2014·Acta Physiologica·A Bondke Persson, P B Persson
Nov 21, 2012·Brain Injury : [BI]·Amanda McIntyreRobert W Teasell
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Craig S Atwood, Richard L Bowen
Mar 7, 2013·Journal of Zhejiang University. Science. B·Xian-fan DingGong-hui Li
Mar 13, 2012·Experimental Gerontology·Angelo Scuteri, Edward G Lakatta
Jun 15, 2010·Neurobiology of Aging·Sivan Vadakkadath Meethal, Craig S Atwood
Jan 28, 2015·International Journal of Pharmaceutics·Soon Sik KwonSoo Nam Park
Nov 5, 2014·Frontiers in Cell and Developmental Biology·Lisa Gasperini, Giuseppe Legname
Mar 22, 2014·Frontiers in Aging Neuroscience·Liuyang CaiKaiping Peng
Sep 8, 2010·Mechanisms of Ageing and Development·Julian C LuiJeffrey Baron
May 8, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana C CalvoAurora Martinez
Mar 9, 2005·Journal of Neuropathology and Experimental Neurology·Craig S AtwoodRichard L Bowen
Jul 15, 2005·American Journal of Physiology. Endocrinology and Metabolism·Ana NavarroAlberto Boveris
Jul 25, 2019·Anatomy & Cell Biology·Mohammad-Amin AbdollahifarShabnam Abdi
Sep 10, 2016·Current Pulmonology Reports·Christopher H WigfieldDavid Onsager
Oct 16, 2018·Frontiers in Endocrinology·Sabina BhattaGemma Casadesus
Jan 18, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Niraj Kumar Singh, Husna Firdose
Dec 6, 2012·Biology Open·Bethanie Carney AlmrothHelen Nilsson Sköld
Feb 10, 2020·Gerontology·Silvia MarchionniAntonello Lorenzini

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Related Papers

Experimental Gerontology
C S Atwood, Richard L Bowen
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Linda Partridge
© 2021 Meta ULC. All rights reserved