Living donor liver transplant recipients achieve relatively higher immunosuppressant blood levels than cadaveric recipients

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
James F TrotterGregory T Everson

Abstract

Two recent brief reports suggest that recipients of living donor liver transplants achieve higher levels of immunosuppressive agents than cadaveric (CAD) liver transplant recipients administered the same dose. These results could have important implications regarding the dosing of immunosuppressives in living donor liver transplant recipients. We report our findings relative to immunosuppressive doses and levels in a cohort of 46 living donor liver transplant recipients. Immunosuppressive blood levels and doses were recorded weeks 1, 2, 3, and 4 and months 2, 3, 4, 5, and 6 for 46 living donor liver transplant recipients and 66 matched CAD liver transplant recipients who underwent transplantation between August 1997 and May 2001. The ratio of level to dose also was recorded at each interval. The mean overall cyclosporine A dose was similar in living donor liver transplant recipients (323 mg/d) compared with CAD recipients (344 mg/d; P = not significant [NS]). The mean overall tacrolimus dose was 15% lower in patients who underwent living donor liver transplantation (LDLT; 5.7 mg/d) than CAD transplantation (6.7 mg/d), although statistical significance was not achieved (P =.08). The mean overall cyclosporine A level was 18% high...Continue Reading

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Citations

Nov 1, 2002·Current Treatment Options in Gastroenterology·James F. Trotter
Oct 23, 2002·Alimentary Pharmacology & Therapeutics·P H Hayashi, J F Trotter
Oct 4, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gregory T Everson
Sep 29, 2006·Transplantation·Sheung Tat Fan
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Jun 21, 2005·Alimentary Pharmacology & Therapeutics·J F TrotterU Christians
Mar 9, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Constantino FondevilaJuan C García-Valdecasas
May 11, 2012·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A Taki-EldinS-S Zheng
Oct 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kim M Olthoff
Mar 30, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Elizabeth J CareyDavid C Mulligan
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Koichi TanakaChristian Moench
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Nov 4, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hui TianRaman Venkataramanan
Nov 24, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ruoqing HuangRomil Saxena

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