Living donor liver transplantation for end-stage hepatitis C

Transplantation Proceedings
Y SugawaraM Makuuchi

Abstract

Living donor liver transplantation is important for patients with end-stage viral hepatitis because of the shortage of organs from deceased donors. However, preliminary results indicate that living liver donation might be disadvantageous for hepatitis C virus-positive patients. Twenty-seven patients who underwent living donor liver transplantation for hepatitis C virus cirrhosis preemptively received antiviral therapy using interferon-alpha2b and ribavirin, which was started an average of 32 days after the operation and continued for at least 6 months thereafter. The serum hepatitis C virus RNA became negative in the 8 of 16 patients with more than 1 year follow-up. The cumulative 3-year patient survival was 85%, which was comparable to that of hepatitis C virus negative patients (n = 93; 90%). Preemptive antiviral therapy after transplantation may be necessary for satisfactory results after living donor liver transplantation.

Citations

Dec 24, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Tim ScholzUNKNOWN Levertransplantasjonsgruppen ved Oslo universitetssykehus, Rikshospitalet
Jan 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Patrick G NorthupUNKNOWN Adult-to-Adult Living Donor Liver Transplantation Cohort Study Group
Mar 15, 2005·Journal of Hepatology·Yasuhiko Sugawara, Masatoshi Makuuchi
Feb 14, 2006·British Medical Bulletin·Yasuhiko Sugawara, Masatoshi Makuuchi
Feb 20, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Siddharth MehrotraSamiran Nundy

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