Abstract
Studies on living donor kidney transplantation primarily address the recipients; few publications focus on kidney donors. The aim of the present study was to detect changes in and compensations of defined parameters of anemia and inflammation in the immediate postnephrectomy period. We included six living kidney donors who underwent an open anterior-extraperitoneal nephrectomy. We excluded donors with complications, such as significant blood loss or infection. Blood samples were taken before nephrectomy as well as on postoperative days 1, 3, 5, and 7, and at discharge for measurements of hemoglobin (Hb), serum erythropoietin (Epo), reticulocytes (Reti), pentraxin 3 (PTX3), and C-reactive protein (CRP). There was a significant decrease in Hb (>3 g/dL), reaching a maximum on day 3 followed by a significant threefold increase in Epo levels on day 5 and a nonsignificant elevation of Reti count. CRP increased approximately 80-fold on day 3. PTX3 showed a similar course, peaking on day 3 with an approximate 70-fold increase. After living donor nephrectomy, there was an unexpectedly pronounced inflammatory reaction in the absence of any signs of bacterial infection simultaneous with a significant decrease in Hb. These parameters impro...Continue Reading
References
Jan 1, 1992·Nephron·J GochB G Danielson
Aug 10, 2000·Transplantation·R R RomeroA Majluf-Cruz
Sep 19, 2000·The Journal of Urology·O ShvartsA Belldegrun
Apr 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anders HartmannHallvard Holdaas
Jun 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Arthur J MatasFrancis L Delmonico
Oct 29, 2003·Clinical Nephrology·A M TeppoC Grönhagen-Riska
Nov 8, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael SiebelsAlfons Hofstetter
Dec 11, 2003·The Journal of Urology·Keiicho ItoMasaru Murai
Jun 12, 2004·The Journal of Laboratory and Clinical Medicine·Michael Y TsaiArthur J Matas
Oct 13, 2004·Circulation·Roberto LatiniUNKNOWN Lipid Assessment Trial Italian Network (LATIN) Investigators
Nov 2, 2004·Clinical Transplantation·Siren SezerMehmet Haberal
Apr 14, 2005·JAMA : the Journal of the American Medical Association·Michael G ShlipakBruce Psaty
Apr 26, 2005·Transplantation·Edith M SimmonsJonathan Himmelfarb
Jul 9, 2005·Transplantation·Alfonso M Cueto-ManzanoJosefina Alberú
Citations
Dec 19, 2008·BMC Nephrology·Robert G FassettJeff S Coombes
Nov 3, 2007·American Journal of Nephrology·Shai EfratiJoshua Weissgarten
Feb 25, 2009·Clinical and Experimental Medicine·Michela ZanettiRocco Barazzoni
Dec 27, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pavel KunesJan Krejsek
Oct 17, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L AkmanN Askar
Sep 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Ho-Won LeeKyoungho Suk
Sep 27, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Honghao WangXueqiang Hu
Sep 25, 2007·Nephron. Clinical Practice·Ann YoungUNKNOWN Donor Nephrectomy Outcomes Research (DONOR) Network
Feb 9, 2021·Hypertension·Anna M PriceJonathan N Townend