Living kidney donation: anemia and inflammation in the early postoperative period

Transplantation Proceedings
D J HampelR Schindler

Abstract

Studies on living donor kidney transplantation primarily address the recipients; few publications focus on kidney donors. The aim of the present study was to detect changes in and compensations of defined parameters of anemia and inflammation in the immediate postnephrectomy period. We included six living kidney donors who underwent an open anterior-extraperitoneal nephrectomy. We excluded donors with complications, such as significant blood loss or infection. Blood samples were taken before nephrectomy as well as on postoperative days 1, 3, 5, and 7, and at discharge for measurements of hemoglobin (Hb), serum erythropoietin (Epo), reticulocytes (Reti), pentraxin 3 (PTX3), and C-reactive protein (CRP). There was a significant decrease in Hb (>3 g/dL), reaching a maximum on day 3 followed by a significant threefold increase in Epo levels on day 5 and a nonsignificant elevation of Reti count. CRP increased approximately 80-fold on day 3. PTX3 showed a similar course, peaking on day 3 with an approximate 70-fold increase. After living donor nephrectomy, there was an unexpectedly pronounced inflammatory reaction in the absence of any signs of bacterial infection simultaneous with a significant decrease in Hb. These parameters impro...Continue Reading

References

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Citations

Dec 27, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pavel KunesJan Krejsek
Oct 17, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L AkmanN Askar
Sep 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Ho-Won LeeKyoungho Suk
Sep 27, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Honghao WangXueqiang Hu
Sep 25, 2007·Nephron. Clinical Practice·Ann YoungUNKNOWN Donor Nephrectomy Outcomes Research (DONOR) Network
Feb 9, 2021·Hypertension·Anna M PriceJonathan N Townend

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